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A single nucleotide polymorphism of PLIN2 is associated with nonalcoholic steatohepatitis and causes phenotypic changes in hepatocyte lipid droplets: A pilot study.PLIN2的单核苷酸多态性与非酒精性脂肪性肝炎相关，并导致肝细胞脂滴的表型变化：一项初步研究。
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 May;1865(5):158637. doi: 10.1016/j.bbalip.2020.158637. Epub 2020 Jan 23.
2
Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions. perilipin-2 通过不同的肝细胞和肝外细胞作用机制促进肥胖和进行性脂肪性肝病的发生。
J Physiol. 2019 Mar;597(6):1565-1584. doi: 10.1113/JP277140. Epub 2019 Jan 2.
3
Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha.用人多能干细胞衍生的未成熟类肝细胞模拟非酒精性脂肪性肝病揭示了PLIN2的激活并证实了过氧化物酶体增殖物激活受体α的调节功能。
Stem Cells Dev. 2016 Aug 1;25(15):1119-33. doi: 10.1089/scd.2015.0383. Epub 2016 Jul 15.
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The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity.人类肝脏形成大脂滴的倾向与 PNPLA3 多态性、INSIG1 和 NPC1L1 表达降低以及纤维生成能力增加有关。
Int J Mol Sci. 2021 Jun 5;22(11):6100. doi: 10.3390/ijms22116100.
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Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome.perilipin-2缺失通过干扰固醇调节元件结合蛋白（SREBP）的激活和改变肝脏脂质组来损害肝脏脂质积累。
J Biol Chem. 2016 Nov 11;291(46):24231-24246. doi: 10.1074/jbc.M116.759795. Epub 2016 Sep 27.
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Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.肝脏特异性缺失 perilipin 2 可减轻饮食诱导的肝脂肪变性、炎症和纤维化。
Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G726-38. doi: 10.1152/ajpgi.00436.2015. Epub 2016 Mar 11.
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Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression.活性氧诱导 HepG2 细胞脂滴积累通过增加 perilipin 2 表达。
Int J Mol Sci. 2018 Nov 2;19(11):3445. doi: 10.3390/ijms19113445.
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Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease.脂质负荷人肝细胞培养的基因组学可用于筛选治疗非酒精性脂肪性肝病的药物靶点。
BMC Med Genomics. 2018 Dec 14;11(1):111. doi: 10.1186/s12920-018-0438-7.
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Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis.人类脂肪肝疾病的基因组学揭示了在单纯性脂肪变性和非酒精性脂肪性肝炎中与脂滴相关的基因调控存在机制上的联系。
Transl Res. 2016 Nov;177:41-69. doi: 10.1016/j.trsl.2016.06.003. Epub 2016 Jun 16.
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Decreased PEDF Promotes Hepatic Fatty Acid Uptake and Lipid Droplet Formation in the Pathogenesis of NAFLD.PEDF 减少促进 NAFLD 发病机制中的肝脂肪酸摄取和脂滴形成。
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Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression.MASH进展过程中肝线粒体亚群的功能区室化
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Cardiometabolic risk factors in MASLD patients with HCC: the other side of the coin.伴有 HCC 的 MASLD 患者的心脏代谢危险因素：硬币的另一面。
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Analysis of gene expression changes during lipid droplet formation in HepG2 human liver cancer cells.对HepG2人肝癌细胞中脂滴形成过程中基因表达变化的分析。
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A missense variant in human perilipin 2 ( Ser251Pro) reduces hepatic steatosis in mice.人类围脂滴蛋白2中的一个错义变体（Ser251Pro）可减轻小鼠的肝脂肪变性。
JHEP Rep. 2023 Oct 11;6(1):100902. doi: 10.1016/j.jhepr.2023.100902. eCollection 2024 Jan.
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Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.平行 CRISPR-Cas9 筛选鉴定 PLIN2 和脂滴调控的机制。
Dev Cell. 2023 Sep 25;58(18):1782-1800.e10. doi: 10.1016/j.devcel.2023.07.001. Epub 2023 Jul 25.
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Perilipins at a glance.脂肪滴包被蛋白概述。
J Cell Sci. 2022 Mar 1;135(5). doi: 10.1242/jcs.259501. Epub 2022 Mar 9.
7
Genetics Is of the Essence to Face NAFLD.遗传学对于应对非酒精性脂肪性肝病至关重要。
Biomedicines. 2021 Sep 30;9(10):1359. doi: 10.3390/biomedicines9101359.
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Mitochondrial Mutations and Genetic Factors Determining NAFLD Risk.线粒体突变与决定非酒精性脂肪性肝病风险的遗传因素
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Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD.肝内脂滴：NAFLD 中能量储存与代谢功能障碍之间的平衡作用。
Mol Metab. 2021 Aug;50:101115. doi: 10.1016/j.molmet.2020.101115. Epub 2020 Nov 10.

本文引用的文献

1
Spatial compartmentalization of lipid droplet biogenesis.脂滴生物发生的空间区隔化。
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jan;1865(1):158499. doi: 10.1016/j.bbalip.2019.07.008. Epub 2019 Jul 25.
2
Hepatic stellate cells retain retinoid-laden lipid droplets after cellular transdifferentiation into activated myofibroblasts.肝星状细胞在细胞向激活的肌成纤维细胞转化后保留富含视黄醇的脂滴。
Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G713-G721. doi: 10.1152/ajpgi.00251.2017. Epub 2018 Jul 19.
3
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention.非酒精性脂肪性肝病和非酒精性脂肪性肝炎的全球负担：趋势、预测、危险因素和预防。
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20. doi: 10.1038/nrgastro.2017.109. Epub 2017 Sep 20.
4
Lipid droplet functions beyond energy storage.脂滴的功能不仅仅是储存能量。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1260-1272. doi: 10.1016/j.bbalip.2017.07.006. Epub 2017 Jul 19.
5
Control of lipid droplet fusion and growth by CIDE family proteins.CIDE 家族蛋白对脂滴融合和生长的调控。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1197-1204. doi: 10.1016/j.bbalip.2017.06.009. Epub 2017 Jun 23.
6
Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation.建立脂滴蛋白质组学：脂滴蛋白靶向和降解的机制。
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1166-1177. doi: 10.1016/j.bbalip.2017.06.006. Epub 2017 Jun 13.
7
Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis.磷脂酰胆碱转运蛋白/StarD2在小鼠实验性脂肪性肝炎中促进微泡性脂肪变性和肝损伤。
Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G50-G61. doi: 10.1152/ajpgi.00379.2016. Epub 2017 Apr 6.
8
Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.肝脏特异性缺失 perilipin 2 可减轻饮食诱导的肝脂肪变性、炎症和纤维化。
Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G726-38. doi: 10.1152/ajpgi.00436.2015. Epub 2016 Mar 11.
9
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.全球非酒精性脂肪性肝病流行病学——患病率、发病率和结局的荟萃分析评估。
Hepatology. 2016 Jul;64(1):73-84. doi: 10.1002/hep.28431. Epub 2016 Feb 22.
10
The perilipin 2 (PLIN2) gene Ser251Pro missense mutation is associated with reduced insulin secretion and increased insulin sensitivity in Italian obese subjects. perilipin 2（PLIN2）基因 Ser251Pro 错义突变与意大利肥胖受试者胰岛素分泌减少和胰岛素敏感性增加有关。
Diabetes Metab Res Rev. 2016 Sep;32(6):550-6. doi: 10.1002/dmrr.2751. Epub 2015 Nov 11.

A single nucleotide polymorphism of PLIN2 is associated with nonalcoholic steatohepatitis and causes phenotypic changes in hepatocyte lipid droplets: A pilot study.

作者信息

Faulkner Claire S, White Collin M, Shah Vijay H, Jophlin Loretta L

机构信息

University of Nebraska Medical Center (UNMC), Department of Internal Medicine, Omaha, NE, United States of America; Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, MN, United States of America.

Washington University, St. Louis, MO, United States of America.

出版信息

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 May;1865(5):158637. doi: 10.1016/j.bbalip.2020.158637. Epub 2020 Jan 23.

DOI:10.1016/j.bbalip.2020.158637
PMID:31981756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8108536/
Abstract
摘要