• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

胞质分裂阻滞淋巴细胞中的微核作为职业性接触烷化剂类细胞毒性药物的指标。

Micronuclei in cytokinesis-blocked lymphocytes as an index of occupational exposure to alkylating cytostatic drugs.

作者信息

Yager J W, Sorsa M, Selvin S

机构信息

Institute of Occupational Health, Helsinki, Finland.

出版信息

IARC Sci Publ. 1988(89):213-6.

PMID:3198202
Abstract

Micronucleated peripheral blood lymphocytes were analysed in cytochalasin-B-treated binucleated lymphocytes using cytocentrifuged preparations. Increased numbers of micronuclei were observed in lymphocytes of groups of workers from industry and hospitals potentially exposed to cyclophosphamide. The finding was independent of the age of the subjects, which was also correlated with micronuclei formation.

摘要

使用细胞离心涂片法,对经细胞松弛素B处理的双核淋巴细胞中的微核化外周血淋巴细胞进行分析。在可能接触环磷酰胺的工业和医院工作人员组的淋巴细胞中,观察到微核数量增加。这一发现与受试者的年龄无关,而年龄也与微核形成相关。

相似文献

1
Micronuclei in cytokinesis-blocked lymphocytes as an index of occupational exposure to alkylating cytostatic drugs.胞质分裂阻滞淋巴细胞中的微核作为职业性接触烷化剂类细胞毒性药物的指标。
IARC Sci Publ. 1988(89):213-6.
2
Micronuclei in peripheral blood from patients after cytostatic therapy mainly arise ex vivo from persistent damage.接受细胞抑制疗法的患者外周血中的微核主要在体外因持续性损伤而产生。
Mutagenesis. 2009 Jul;24(4):351-7. doi: 10.1093/mutage/gep015. Epub 2009 May 7.
3
[The micronuclei detection test in stimulated human peripheral lymphocytes using cytochalasin B].[细胞松弛素B诱导人外周血淋巴细胞微核检测试验]
Cas Lek Cesk. 1989 Apr 28;128(18):568-70.
4
Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: a multi-biomarker approach.克罗地亚医疗保健工作者职业接触细胞毒性药物的遗传毒性风险评估:一种多生物标志物方法。
Int J Hyg Environ Health. 2009 Jul;212(4):414-31. doi: 10.1016/j.ijheh.2008.10.001. Epub 2008 Dec 1.
5
[The micronucleus test in human peripheral lymphocytes].[人类外周血淋巴细胞微核试验]
Cesk Farm. 1990 May;39(3):131-3.
6
Cytogenetic monitoring of pesticide sprayers.农药喷雾器操作人员的细胞遗传学监测。
Environ Res. 1997 Nov;75(2):113-8. doi: 10.1006/enrs.1997.3753.
7
Analysis of micronuclei in peripheral blood lymphocytes of traffic wardens: effects of exposure, metabolic genotypes, and inhibition of excision repair in vitro by ARA-C.交通协管员外周血淋巴细胞微核分析:暴露影响、代谢基因型及阿糖胞苷体外对切除修复的抑制作用
Environ Mol Mutagen. 2003;41(2):126-30. doi: 10.1002/em.10138.
8
Cytogenetic biomonitoring in traffic police workers: micronucleus test in peripheral blood lymphocytes.交警工作人员的细胞遗传学生物监测:外周血淋巴细胞微核试验
Environ Mol Mutagen. 1997;30(4):396-402.
9
Frequency of micronuclei in peripheral blood lymphocytes from subjects occupationally exposed to low levels of ionizing radiation.职业性暴露于低水平电离辐射的受试者外周血淋巴细胞中的微核频率。
Mutat Res. 2004 Nov 14;564(1):83-8. doi: 10.1016/j.mrgentox.2004.07.012.
10
Micronucleus frequency in women with genital Chlamydia Trachomatis infection before and after therapy.沙眼衣原体生殖道感染女性治疗前后的微核频率。
Mutat Res. 2006 Sep 19;608(1):43-8. doi: 10.1016/j.mrgentox.2006.05.002. Epub 2006 Jun 13.

引用本文的文献

1
The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations.胞质分裂阻滞微核技术及其在人群遗传毒性研究中的应用。
Environ Health Perspect. 1993 Oct;101 Suppl 3(Suppl 3):101-7. doi: 10.1289/ehp.93101s3101.