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自组装纳米颗粒在动脉粥样硬化诊断与治疗中的最新进展

Recent advances of self-assembled nanoparticles in the diagnosis and treatment of atherosclerosis.

作者信息

Aili Tuersun, Zong Jia-Bin, Zhou Yi-Fan, Liu Yu-Xiao, Yang Xiang-Liang, Hu Bo, Wu Jie-Hong

机构信息

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

出版信息

Theranostics. 2024 Nov 4;14(19):7505-7533. doi: 10.7150/thno.100388. eCollection 2024.

DOI:10.7150/thno.100388
PMID:39659570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626940/
Abstract

Atherosclerosis remains a significant global health challenge, with its related conditions as the leading cause of death, underscoring the urgent need for enhanced diagnostic and therapeutic approaches. Recently, self-assembled nanoparticles (SANPs) have shown remarkable promise in treating atherosclerosis, attributed to their superior bioavailability, biodegradability, biocompatibility, and ease of functional modification. Numerous SANP variants, such as DNA origami, metal-organic frameworks (MOFs), nanozymes, peptide-based nanoparticles, and self-assembled prodrug nanoparticles, have been engineered, extending their utility in targeted drug delivery and imaging. Advances in fabrication technologies, including microfluidic techniques, allow for precise and scalable SANP production, while innovative nanoparticle designs-such as stimuli-responsive and carrier-free variants-enhance pharmacokinetic properties. The deployment of SANPs in atherosclerosis has introduced a range of diagnostic and therapeutic solutions, from non-invasive imaging and stimuli-responsive drug delivery to vaccination, theranostics, and biosensing. This review consolidates the recent progress in SANP applications for atherosclerosis, emphasizing their transformative potential in disease management.

摘要

动脉粥样硬化仍然是一项重大的全球健康挑战，其相关病症是主要死因，这凸显了迫切需要改进诊断和治疗方法。最近，自组装纳米颗粒（SANPs）在治疗动脉粥样硬化方面显示出显著前景，这归因于它们卓越的生物利用度、可生物降解性、生物相容性以及易于进行功能修饰。已经设计出了多种SANP变体，如DNA折纸、金属有机框架（MOFs）、纳米酶、基于肽的纳米颗粒和自组装前药纳米颗粒，从而扩展了它们在靶向药物递送和成像方面的应用。制造技术的进步，包括微流控技术，使得能够精确且可扩展地生产SANP，而创新的纳米颗粒设计，如刺激响应型和无载体变体，则增强了药代动力学特性。SANPs在动脉粥样硬化中的应用带来了一系列诊断和治疗解决方案，从无创成像和刺激响应型药物递送到疫苗接种、诊疗一体化和生物传感。本综述总结了SANPs在动脉粥样硬化应用方面的最新进展，强调了它们在疾病管理中的变革潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6012/11626940/de40f2631c65/thnov14p7505g010.jpg
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