Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100190, China.
Adv Mater. 2020 Mar;32(10):e1907491. doi: 10.1002/adma.201907491. Epub 2020 Jan 27.
The effectiveness of commercial bone adhesives is known to be hampered by the weak efficacy of cell ingrowth. The strategy of macropore-forming, especially bioactive macropores, holds considerable promise to circumvent this problem, thereby promoting fracture healing. Herein, a class of bioactive glass-involved macropore-embedded bone adhesives is developed, which is capable of facilitating the migration of bone-derived mesenchymal stromal cells into the adhesive layer and differentiation into osteocytes. The integration of bioactive glass-particle-encapsulated porogens in the bone adhesives is key to this approach. A robust instant bonding on the bone adhesive and a high efficiency of bone regeneration on a mouse skull are observed, both of which are vital for clinical applications and personalized surgical procedures. This work represents a general strategy to design biomaterials with high cell-ingrowth efficacy.
商业骨黏合剂的有效性已知受到细胞内生长效果不佳的阻碍。大孔形成策略，特别是生物活性大孔，具有很大的潜力来解决这个问题，从而促进骨折愈合。本文开发了一类涉及生物活性玻璃的大孔嵌入骨黏合剂，能够促进骨源性间充质基质细胞迁移到黏合层并分化为成骨细胞。生物活性玻璃颗粒封装的造孔剂在骨黏合剂中的整合是这种方法的关键。在骨黏合剂上实现了强大的即时黏合和在小鼠颅骨上的高效骨再生，这对于临床应用和个性化手术程序都是至关重要的。这项工作代表了一种设计具有高细胞内生长效果的生物材料的通用策略。
