Ornaghi Heitor Luiz, Monticeli Francisco Maciel, Agnol Lucas Dall
Mantova Indústria de Tubos Plásticos Ltd.a., R. Isidoro Fadanelli, 194-Centenário, Caxias do Sul 95045-137, RS, Brazil.
Department of Aerospace Structures and Materials, Faculty of Aerospace Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands.
Polymers (Basel). 2023 Oct 9;15(19):4034. doi: 10.3390/polym15194034.
In the past decades, there has been a significant increase in the use of polymers for biomedical applications. The global medical polymer market size was valued at USD 19.92 billion in 2022 and is expected to grow at a CAGR of 8.0% from 2023 to 2030 despite some limitations, such as cost (financial limitation), strength compared to metal plates for bone fracture, design optimization and incorporation of reinforcement. Recently, this increase has been more pronounced due to important advances in synthesis and modification techniques for the design of novel biomaterials and their behavior in vitro and in vivo. Also, modern medicine allows the use of less invasive surgeries and faster surgical sutures. Besides their use in the human body, polymer biomedical materials must have desired physical, chemical, biological, biomechanical, and degradation properties. This review summarizes the use of polymers for biomedical applications, mainly focusing on hard and soft tissues, prosthetic limbs, dental applications, and bone fracture repair. The main properties, gaps, and trends are discussed.
在过去几十年中，用于生物医学应用的聚合物的使用量显著增加。2022年全球医用聚合物市场规模估值为199.2亿美元，尽管存在一些限制因素，如成本（资金限制）、与骨折金属板相比的强度、设计优化以及增强材料的加入，但预计从2023年到2030年将以8.0%的复合年增长率增长。最近，由于新型生物材料设计的合成和改性技术及其体外和体内行为方面的重要进展，这种增长更为显著。此外，现代医学允许使用侵入性较小的手术和更快的手术缝合线。除了在人体中的应用外，聚合物生物医学材料必须具备所需的物理、化学、生物、生物力学和降解性能。本综述总结了聚合物在生物医学应用中的使用情况，主要侧重于硬组织和软组织、假肢、牙科应用以及骨折修复。讨论了主要性能、差距和趋势。
