Division of Dysmorphology and Teratology, Department of Pediatrics, University of California, San Diego, San Diego, California.
Department of Family Medicine and Public Health, University of California, San Diego, San Diego, California.
Breastfeed Med. 2020 Mar;15(3):155-162. doi: 10.1089/bfm.2019.0277. Epub 2020 Jan 27.
Human milk is the normative standard for infant/toddler nutrition. To better understand human milk's imprinting on health, and inform complex decisions about maternal medication, substance use, and other exposures during lactation, researchers at University of California San Diego (UC San Diego) established Mommy's Milk, a Human Milk Research Biorepository (HMB). The HMB was founded in 2014 with the goal of building a constant but rotating inventory of 3,000 human milk samples available for future research. Following informed consent, women in the United States or Canada provide 50 mL up to a full pump of expressed breast milk. Participants are also interviewed about their sociodemographic characteristics, pregnancy history, dietary intake, maternal stress, anxiety and depression, breastfeeding behaviors, and signs and symptoms of potential adverse reactions in the offspring. Data on growth of the infant/toddler are captured from medical records, and neurodevelopmental assessments are conducted longitudinally. Sample collections occur at UC San Diego, community sites, or the woman's home, and are aliquoted and stored at -80°C. To date, 1,362 unique women have contributed to the HMB. The majority of mothers were between the ages of 31-35, and identified as White. The range of ages of breastfed offspring was well-represented through 23 months. The HMB is a well-characterized, accessible research resource that can contribute to better understanding of the characteristics of human milk, and potential effects of maternal medications, substances, and other environmental agents on the health and development of the breastfed infant/toddler.
人乳是婴儿/幼儿营养的标准。为了更好地了解人乳对健康的影响，并为哺乳期母亲用药、物质使用和其他暴露等复杂决策提供信息，加州大学圣地亚哥分校（UCSD）的研究人员建立了 Mommy's Milk，这是一个人乳研究生物库（HMB）。该生物库成立于 2014 年，目标是建立一个 3000 个人乳样本的恒定但不断旋转的库存，以备未来研究使用。在获得知情同意后，来自美国或加拿大的女性提供 50 毫升至一整泵的母乳。参与者还接受了关于其社会人口特征、妊娠史、饮食摄入、产妇压力、焦虑和抑郁、母乳喂养行为以及潜在不良反应迹象和症状的访谈。婴儿/幼儿的生长数据来自医疗记录，神经发育评估是纵向进行的。样本采集在加州大学圣地亚哥分校、社区场所或女性家中进行，然后等分并储存在-80°C。迄今为止，已有 1362 名独特的女性为 HMB 做出了贡献。大多数母亲的年龄在 31-35 岁之间，被认定为白人。通过 23 个月，代表了母乳喂养婴儿/幼儿的年龄范围。HMB 是一个特征良好、易于获取的研究资源，可以帮助更好地了解人乳的特征，以及母亲用药、物质和其他环境因素对母乳喂养婴儿/幼儿健康和发育的潜在影响。
