Skotzek B, Sander T, Zimmermann J, Kölmel H W
Department of Neurology, Universitätsklinikum Rudolf-Virchow, Freie Universität Berlin, F.R.G.
J Neuroimmunol. 1988 Dec;20(2-3):151-2. doi: 10.1016/0165-5728(88)90148-8.
Matched samples of serum and cerebrospinal fluid (CSF) from 15 human immunodeficiency virus (HIV)-infected patients were examined after isoelectric focusing. The appearance of oligoclonal bands only in the CSF could indicate the primary HIV infection of CNS in early stages of the disease. Later, the increasing number of autochthonous oligoclonal bands in the CSF suggested locally synthesized IgG against opportunistic infections. Because of the immunodeficiency, T cell independent polyclonal B cell stimulation might mask the oligoclonal pattern.
对15例人类免疫缺陷病毒（HIV）感染患者的血清和脑脊液（CSF）配对样本进行等电聚焦后检查。仅在脑脊液中出现寡克隆带可能表明在疾病早期中枢神经系统受到原发性HIV感染。后来，脑脊液中自身寡克隆带数量的增加提示针对机会性感染的局部合成IgG。由于免疫缺陷，非T细胞依赖性多克隆B细胞刺激可能会掩盖寡克隆模式。
