Center for Theoretical Biological Physics, Rice University, Houston, TX, United States of America.
Theoretical and Computational Physics Laboratory, University of Costa Rica, San José, Costa Rica.
PLoS One. 2020 Jan 28;15(1):e0222900. doi: 10.1371/journal.pone.0222900. eCollection 2020.
Mosquito-borne diseases have become a significant health issue in many regions around the world. For tropical countries, diseases such as Dengue, Zika, and Chikungunya, became epidemic in the last decades. Health surveillance reports during this period were crucial in providing scientific-based information to guide decision making and resources allocation to control outbreaks. In this work, we perform data analysis of the last Chikungunya epidemics in the city of Rio de Janeiro by applying a compartmental mathematical model. Sensitivity analyses were performed in order to describe the contribution of each parameter to the outbreak incidence. We estimate the "basic reproduction number" for those outbreaks and predict the potential epidemic outbreak of the Mayaro virus. We also simulated several scenarios with different public interventions to decrease the number of infected people. Such scenarios should provide insights about possible strategies to control future outbreaks.
蚊媒疾病已成为世界许多地区的一个重大健康问题。对于热带国家来说,登革热、寨卡和基孔肯雅热等疾病在上个世纪几十年中流行起来。在此期间,卫生监测报告在提供基于科学的信息以指导决策和资源分配以控制疫情方面发挥了关键作用。在这项工作中,我们通过应用房室数学模型对里约热内卢市最近的基孔肯雅热疫情进行数据分析。我们进行了敏感性分析,以描述每个参数对疫情发生的贡献。我们估计了这些疫情的“基本繁殖数”,并预测了马亚罗病毒的潜在流行疫情。我们还模拟了几种不同公共干预措施的情景,以减少感染人数。这些情景应该可以提供关于控制未来疫情的可能策略的见解。