Velazquez-Albino Ambar C, Imhoff Eric Daniel, Rinaldi-Ramos Carlos M
Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA.
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, USA.
Sci Adv. 2025 Jan 10;11(2):eado7356. doi: 10.1126/sciadv.ado7356. Epub 2025 Jan 8.
Magnetic particle imaging (MPI) is an emerging imaging modality with exciting biomedical applications, such as cell tracking, blood pool imaging, and image-guided magnetic hyperthermia. MPI is unique in that signal is generated entirely by synthetic nanoparticle tracers, motivating precise engineering of magnetic nanoparticle properties including size, shape, composition, and coating to address the needs of specific applications. However, success in many applications and in clinical transition requires development of high-sensitivity and high-resolution tracers, for which there is considerable room for improvement. This review summarizes recent advancements in MPI tracer synthesis and compares reported tracers in terms of sensitivity and resolution. In making these comparisons, we point out inconsistencies in reporting of MPI tracer properties. To overcome this challenge, we propose a list of properties to standardize characterization and reporting of new MPI tracers and improve communication within the field.
磁粒子成像(MPI)是一种新兴的成像方式,具有令人兴奋的生物医学应用,如细胞追踪、血池成像和图像引导磁热疗。MPI的独特之处在于,信号完全由合成纳米颗粒示踪剂产生,这促使人们对磁性纳米颗粒的性质进行精确设计,包括尺寸、形状、组成和涂层,以满足特定应用的需求。然而,要在许多应用和临床转化中取得成功,需要开发高灵敏度和高分辨率的示踪剂,而这方面仍有很大的改进空间。本综述总结了MPI示踪剂合成的最新进展,并在灵敏度和分辨率方面对已报道的示踪剂进行了比较。在进行这些比较时,我们指出了MPI示踪剂性质报告中的不一致之处。为了克服这一挑战,我们提出了一系列性质,以规范新MPI示踪剂的表征和报告,并改善该领域内的交流。
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