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用于磁粒子成像(MPI)的工程纳米粒子的进展。

Advances in engineering nanoparticles for magnetic particle imaging (MPI).

作者信息

Velazquez-Albino Ambar C, Imhoff Eric Daniel, Rinaldi-Ramos Carlos M

机构信息

Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, USA.

出版信息

Sci Adv. 2025 Jan 10;11(2):eado7356. doi: 10.1126/sciadv.ado7356. Epub 2025 Jan 8.


DOI:10.1126/sciadv.ado7356
PMID:39772674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11708890/
Abstract

Magnetic particle imaging (MPI) is an emerging imaging modality with exciting biomedical applications, such as cell tracking, blood pool imaging, and image-guided magnetic hyperthermia. MPI is unique in that signal is generated entirely by synthetic nanoparticle tracers, motivating precise engineering of magnetic nanoparticle properties including size, shape, composition, and coating to address the needs of specific applications. However, success in many applications and in clinical transition requires development of high-sensitivity and high-resolution tracers, for which there is considerable room for improvement. This review summarizes recent advancements in MPI tracer synthesis and compares reported tracers in terms of sensitivity and resolution. In making these comparisons, we point out inconsistencies in reporting of MPI tracer properties. To overcome this challenge, we propose a list of properties to standardize characterization and reporting of new MPI tracers and improve communication within the field.

摘要

磁粒子成像(MPI)是一种新兴的成像方式,具有令人兴奋的生物医学应用,如细胞追踪、血池成像和图像引导磁热疗。MPI的独特之处在于,信号完全由合成纳米颗粒示踪剂产生,这促使人们对磁性纳米颗粒的性质进行精确设计,包括尺寸、形状、组成和涂层,以满足特定应用的需求。然而,要在许多应用和临床转化中取得成功,需要开发高灵敏度和高分辨率的示踪剂,而这方面仍有很大的改进空间。本综述总结了MPI示踪剂合成的最新进展,并在灵敏度和分辨率方面对已报道的示踪剂进行了比较。在进行这些比较时,我们指出了MPI示踪剂性质报告中的不一致之处。为了克服这一挑战,我们提出了一系列性质,以规范新MPI示踪剂的表征和报告,并改善该领域内的交流。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/76c12b19706b/sciadv.ado7356-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/053b91426e91/sciadv.ado7356-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/5c387af9a031/sciadv.ado7356-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/64d679d7f2ba/sciadv.ado7356-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/ea867ac29091/sciadv.ado7356-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/7200fd97f88a/sciadv.ado7356-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/a8bce513124a/sciadv.ado7356-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/76c12b19706b/sciadv.ado7356-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/053b91426e91/sciadv.ado7356-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/5c387af9a031/sciadv.ado7356-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/64d679d7f2ba/sciadv.ado7356-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/ea867ac29091/sciadv.ado7356-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/7200fd97f88a/sciadv.ado7356-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/a8bce513124a/sciadv.ado7356-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9735/11708890/76c12b19706b/sciadv.ado7356-f7.jpg

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引用本文的文献

[1]
Magnetically induced magnetosome chain (MAGiC): A biogenic magnetic-particle-imaging tracer with high performance and navigability.

Sci Adv. 2025-8

[2]
Spillover can limit accurate signal quantification in MPI.

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[3]
Flame-Made Doped Iron Oxide Nanoparticles as Tracers for Magnetic Particle Imaging.

Chem Mater. 2025-5-20

本文引用的文献

[1]
Post-synthesis Oxidation of Superparamagnetic Iron Oxide Nanoparticles to Enhance Magnetic Particle Imaging Performance.

ACS Appl Nano Mater. 2024-1-12

[2]
Magnetic Particle Imaging-Guided Hyperthermia for Precise Treatment of Cancer: Review, Challenges, and Prospects.

Mol Imaging Biol. 2023-12

[3]
Shape Anisotropy-Governed High-Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs.

Small. 2024-2

[4]
Inter-user Comparison for Quantification of Superparamagnetic Iron Oxides with Magnetic Particle Imaging Across Two Institutions Highlights a Need for Standardized Approaches.

Mol Imaging Biol. 2023-10

[5]
First Superferromagnetic Remanence Characterization and Scan Optimization for Super-Resolution Magnetic Particle Imaging.

Nano Lett. 2023-3-8

[6]
Scale-up approach for the preparation of magnetic ferrite nanocubes and other shapes with benchmark performance for magnetic hyperthermia applications.

Nat Protoc. 2023-3

[7]
Recent developments of the reconstruction in magnetic particle imaging.

Vis Comput Ind Biomed Art. 2022-10-1

[8]
Magnetic Particle Imaging of Magnetotactic Bacteria as Living Contrast Agents Is Improved by Altering Magnetosome Arrangement.

Nano Lett. 2022-6-22

[9]
Superferromagnetic Nanoparticles Enable Order-of-Magnitude Resolution & Sensitivity Gain in Magnetic Particle Imaging.

Small Methods. 2021-11

[10]
The sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for cell tracking.

Sci Rep. 2021-11-12

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