Oner L, Kaş H S, Hincal A A
University of Hacettepe, Faculty of Pharmacy, Pharmaceutical Technology Department, Ankara, Turkey.
J Microencapsul. 1988 Jul-Sep;5(3):219-23. doi: 10.3109/02652048809064166.
Microcapsules of zinc sulphate with core: wall ratios of 1:1 and 2:1 were prepared by the coacervation method, using ethylcellulose as the coating material. The prepared microcapsules were separated into batches of 250 and 500 micron in size by sieving. The effects of particle size, the amount of zinc sulphate, and the core: wall ratio on the dissolution kinetics were studied, and evaluated kinetically by the Rosin-Rammler-Sperling-Bennet-Weillbull (RRSBW) distribution.
采用凝聚法，以乙基纤维素为包衣材料，制备了核壳比为1:1和2:1的硫酸锌微胶囊。通过筛分将制备的微胶囊分离成粒径为250微米和500微米的批次。研究了粒径、硫酸锌用量和核壳比对溶解动力学的影响，并通过罗辛-拉姆勒-斯珀林-贝内特-韦布尔（RRSBW）分布进行动力学评估。
