College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Dongjak-gu, Seoul, 06974, Republic of Korea.
Arch Pharm Res. 2020 Jan;43(1):46-57. doi: 10.1007/s12272-020-01206-5. Epub 2020 Jan 28.
Over the past few decades, hyperthermia therapy (HTT) has become one of the most promising strategies to treat cancer. HTT has been applied with nanotechnology to overcome drawbacks such as non-selectivity and invasiveness and to maximize therapeutic efficacy. The high temperature of HTT induces protein denaturation that leads to apoptosis or necrosis. It can also enhance the effects of other cancer therapies because heat-damaged tissues reduce radioresistance and help accumulate anticancer drugs. Gold nanoparticles and superparamagnetic iron oxide with different energy sources are commonly used as hyperthermia agents. New types of nanoparticles such as those whose surface is coated with several polymers and those modified with targeting moieties have been studied as novel HTT agents. In this review, we introduce principles and applications of nanotechnology-based HTT using gold nanoparticles and superparamagnetic iron oxide.
在过去的几十年中，热疗（HTT）已成为治疗癌症最有前途的策略之一。已经将纳米技术应用于 HTT 以克服非选择性和侵袭性等缺点，并最大程度地提高治疗效果。HTT 的高温会导致蛋白质变性，从而导致细胞凋亡或坏死。它还可以增强其他癌症疗法的效果，因为热损伤组织会降低放射抗性并有助于积累抗癌药物。金纳米粒子和具有不同能量源的超顺磁性氧化铁通常用作热疗剂。已经研究了新型纳米粒子，例如表面涂有几种聚合物的纳米粒子和用靶向部分修饰的纳米粒子，作为新型 HTT 剂。在这篇综述中，我们介绍了基于金纳米粒子和超顺磁性氧化铁的纳米技术 HTT 的原理和应用。
