34378 Department of Dermatology, Liverpool Hospital, Sydney, Australia.
98994 Faculty of Medicine, University of New South Wales, Sydney, Australia.
J Cutan Med Surg. 2020 Jan/Feb;24(1):23-27. doi: 10.1177/1203475419874411. Epub 2019 Sep 5.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful nodules, sinus tracts, and significant scarring. Although the pathogenesis of this disease is not well established, there is increasing evidence to suggest that it is an immune-mediated disorder. Previous studies have suggested a relationship between HS and thyroid disease, which is also driven by an autoimmune process. We sought to assess whether an association exists between HS and thyroid disease.
To determine whether HS is associated with thyroid disease via meta-analysis of case-control studies.
A systematic review and meta-analysis was performed according to recommended PRISMA guidelines. Electronic searches were performed using 6 electronic databases from their inception until August 2018. Data were extracted and analyzed according to predefined clinical endpoints. Odds ratio (OR) was used as the summary effect size.
We identified 5 case-controls studies included for meta-analysis. There were a total of 36 103 HS cases compared with 170 517 control cases. We found a significant association between HS and thyroid disease (OR 1.36, 95% CI 1.13-1.64, = 78%, = .001).
This pooled analysis of existing case-control studies to date supports an association between HS and any thyroid disease. Clinicians treating patients with HS should be aware of this potential association with thyroid disease.
化脓性汗腺炎（HS）是一种慢性炎症性疾病，其特征为疼痛性结节、窦道和明显的瘢痕形成。尽管该疾病的发病机制尚未完全确定，但越来越多的证据表明它是一种免疫介导的疾病。先前的研究表明 HS 与甲状腺疾病之间存在关联，而甲状腺疾病也是由自身免疫过程驱动的。我们试图评估 HS 是否与甲状腺疾病之间存在关联。
通过对病例对照研究的荟萃分析，确定 HS 是否与甲状腺疾病有关。
根据推荐的 PRISMA 指南进行系统评价和荟萃分析。使用 6 个电子数据库进行电子检索，检索范围从数据库建立到 2018 年 8 月。根据预设的临床终点提取和分析数据。使用比值比（OR）作为汇总效应量。
我们确定了 5 项病例对照研究进行荟萃分析。共有 36103 例 HS 病例与 170517 例对照病例进行了比较。我们发现 HS 与甲状腺疾病之间存在显著关联（OR 1.36，95%CI 1.13-1.64， = 78%， =.001）。
目前对现有病例对照研究的汇总分析支持 HS 与任何甲状腺疾病之间存在关联。治疗 HS 患者的临床医生应意识到与甲状腺疾病之间存在这种潜在关联。
