Universidade Federal Fluminense, Departamento de Quimica Organica, Programa de Pos-Graduacao em Quimica, Outeiro de Sao Joao Baptista, 24020-141 Niteroi, RJ, Brazil.
Curr Top Med Chem. 2020;20(3):244-255. doi: 10.2174/1568026620666200129100219.
4-Oxoquinoline derivatives constitute an important family of biologically important substances, associated with different bioactivities, which can be synthesized by different synthetic methods, allowing the design and preparation of libraries of substances with specific structural variations capable of modulating their pharmacological action. Over the last years, these substances have been extensively explored by the scientific community in efforts to develop new biologically active agents, with greater efficiency for the treatment of a variety of diseases. Viral infections have been one of the targets of these studies, although to a lesser extent than other diseases such as cancer and bacterial infections. Nevertheless, the literature provides examples that corroborate with the fact that these substances may act on different pharmacological targets in different viral pathogens. This review provides a compilation of some of the major studies published in recent years showing the discovery and/or development of new antiviral oxoquinoline agents, highlighting, whenever possible, their mechanisms of action.
4-氧代喹啉衍生物是一类具有重要生物学意义的物质，具有多种生物活性，可通过不同的合成方法合成，允许设计和制备具有特定结构变化的物质文库，从而调节其药理作用。在过去的几年中，这些物质受到科学界的广泛探索，旨在开发新的具有生物活性的药物，以提高治疗各种疾病的效率。病毒感染一直是这些研究的目标之一，但程度不及癌症和细菌感染等其他疾病。然而，文献中提供了一些例子，证明这些物质可能对不同的病毒病原体的不同药理靶点起作用。本文综述了近年来发表的一些主要研究，展示了新型抗毒氧代喹啉药物的发现和/或开发，强调了其作用机制（如果可能的话）。
