Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Piso, 4. C1428EGA Buenos Aires, Argentina.
Curr Med Chem. 2010;17(18):1858-73. doi: 10.2174/092986710791163975.
Scientific literature provides evidence about the use of steroids as an adjunct treatment to antiviral therapies. Immunomodulatory activity of some steroids would account for the recovery in patients with herpetic and other viral infections. However, in vitro studies have demonstrated a direct antiviral effect of this kind of molecules. In this review we discuss recent reports about the mechanism of antiviral action of steroids from animal and plant origin. Chemical structures of most active compounds are also provided.
科学文献提供了类固醇作为抗病毒治疗辅助手段的使用证据。一些类固醇的免疫调节活性可以解释疱疹和其他病毒感染患者的康复。然而，体外研究已经证明了这种分子的直接抗病毒作用。在这篇综述中，我们讨论了最近关于动物和植物来源的类固醇的抗病毒作用机制的报告。还提供了大多数活性化合物的化学结构。
