Department of Microbiology, Universidade Estadual de Londrina, Londrina, Paraná CP 6001, Brazil.
Future Microbiol. 2020 Jun;15:767-777. doi: 10.2217/fmb-2019-0320. Epub 2020 Jul 23.
Viruses are considered biological entities that possess a genome and can adapt to the environment of living organisms. Since they are obligate intracellular parasites, their cycle of replication can result in cell death, and consequently, some viruses are harmful to mammalian cells and can cause disease in humans. Therefore, the search for substances for the treatment of viral diseases can be accomplished through the use of bacteriophages as models for eukaryotic cell viruses. Thus, this review highlights the main studies identifying substances with antiphage activity in comparison assays involving phages and eukaryotic viruses, in order to explore the potential of these substances as antivirals. As a future perspective, this approach may help at the beginning of an Antiviral Age.
病毒被认为是具有基因组并能适应生物体环境的生物实体。由于它们是专性细胞内寄生虫，它们的复制周期会导致细胞死亡，因此，一些病毒对哺乳动物细胞有害，并可能导致人类疾病。因此，通过使用噬菌体作为真核细胞病毒的模型，可以寻找治疗病毒性疾病的物质。因此，本综述重点介绍了在涉及噬菌体和真核病毒的比较试验中鉴定具有抗噬菌体活性的物质的主要研究，以探索这些物质作为抗病毒药物的潜力。作为未来展望，这种方法可能有助于在抗病毒时代的初期发挥作用。
