J Biomed Nanotechnol. 2020 Jan 1;16(1):1-13. doi: 10.1166/jbn.2020.2878.
Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis . The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.
靶向药物递送系统在癌症治疗中目前已经显示出相当大的临床应用潜力。姜黄素通过增加细胞凋亡和抑制细胞增殖，已经成为多形性胶质母细胞瘤（GBM）治疗的候选抗肿瘤药物。在当前的研究中，我们探索了一种新的靶向药物递送系统，通过自组装措施用姜黄素、MPEG-PLA 和 Fa-PEG-PLA 制备。与游离姜黄素和 Cur/MPEG-PLA 相比，Cur/Fa-PEG-PLA 能显著抑制 GL261 细胞的生长并促进细胞凋亡率。此外，用姜黄素/FA-PEG-PLA 复合物处理荷瘤小鼠后，通过抑制血管生成和促进细胞凋亡，抑制了皮下和颅内肿瘤模型中的肿瘤生长。姜黄素/FA-PEG-PLA 纳米颗粒可能是治疗 GBM 的一种新型药物。
