Department of Neurology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, I.P. Pavlova 185/6, 779 00, Olomouc, Czech Republic.
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 976/3, 775 15, Olomouc, Czech Republic.
Sci Rep. 2020 Jan 29;10(1):1436. doi: 10.1038/s41598-020-58363-2.
The link between dystonia and tremor has been known for decades, but the question of whether they are two separate illnesses or just different manifestations of one disease with the same pathophysiological background remains unanswered. We distinguish two types of tremor in dystonia: dystonic tremor (DT), which appears on the body part affected by dystonia, and tremor associated with dystonia (TAWD), which appears in locations where the dystonia does not occur. In this study, the frequency of occurrence of different forms of tremor was determined by clinical examination in a group of adult-onset isolated cervical dystonia (CD) patients treated with regular local injections of botulinum toxin A in our department. In total, 120 patients were included in the study, of which 70 (58.3%) had DT of the head. TAWD was, in all 14 cases (11.7%), observed on the upper limbs, in the form of static or intentional tremor. The aim of this study was to point out the presence of TAWD as one of the clinical signs of CD. DT occurred in more than half of the patients and appears to be a relatively common part of the clinical picture in patients with CD.
几十年来，人们已经知道肌张力障碍和震颤之间存在联系，但它们是两种独立的疾病，还是同一疾病具有相同病理生理背景的两种不同表现形式，这个问题仍未得到解答。我们在肌张力障碍中区分两种类型的震颤：肌张力障碍性震颤（DT），出现在受肌张力障碍影响的身体部位；以及与肌张力障碍相关的震颤（TAWD），出现在肌张力障碍不发生的部位。在这项研究中，我们通过对我科接受常规局部注射 A 型肉毒毒素治疗的一组成年起病的孤立性颈肌张力障碍（CD）患者进行临床检查，确定了不同形式震颤的发生频率。共有 120 例患者纳入研究，其中 70 例（58.3%）头部有 DT。在所有 14 例（11.7%）患者中，上肢均观察到 TAWD，表现为静止性或意向性震颤。本研究旨在指出 TAWD 是 CD 的临床体征之一。DT 发生在一半以上的患者中，似乎是 CD 患者临床特征中较为常见的一部分。
