Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong, PR China.
Forensic Science Center of Jining Medical University, Jining, Shandong, PR China.
Mol Genet Genomic Med. 2020 Apr;8(4):e1142. doi: 10.1002/mgg3.1142. Epub 2020 Jan 29.
Genetic polymorphisms at 23 short tandem repeat (STR) loci were investigated in 1,215 Jining Han individuals from Jining city, Shandong province, eastern China.
We used population genetic data of 23 autosomal STR loci included in the Huaxia Platinum system to evaluate 1,215 unrelated Chinese Han individuals in the Jining Han population. Allele frequencies and forensic parameters of the STR loci were determined and genetic relationships among the Jining Han and other Chinese populations were evaluated.
In total, we observed 321 alleles, with frequencies ranging from 0.00041 to 0.52222. The combined discrimination power and probability of excluding paternity were 0.99999999999999999999999999919 and 0.99999999962, respectively. No deviations from HWE were observed at any loci. Population comparisons showed that the Xinjiang groups (Uyghur and Kazakh) and the Mongolian and Tibetan groups were isolated, while the Jining Han population clustered together with other populations, except the Guizhou Han population.
This study demonstrated that 23 autosomal STR loci included in the Huaxia Platinum system are highly polymorphic and suitable for personal forensic identification and paternity testing in this population.
在中国东部山东省济宁市，对 1215 名汉族个体的 23 个短串联重复（STR）基因座的遗传多态性进行了研究。
我们使用包括在华夏铂金系统中的 23 个常染色体 STR 基因座的群体遗传学数据，对济宁市汉族的 1215 名无关个体进行评估。确定了 STR 基因座的等位基因频率和法医参数，并评估了济宁市汉族与其他中国人群之间的遗传关系。
总共观察到 321 个等位基因，频率范围从 0.00041 到 0.52222。联合鉴别力和排除亲子关系的概率分别为 0.9999999999999999999999999919 和 0.99999999962。在任何基因座上均未观察到与哈温平衡的偏离。人群比较显示，新疆群体（维吾尔族和哈萨克族）以及蒙古和藏族群体是孤立的，而济宁市汉族群体除了与贵州汉族群体聚类外，还与其他群体聚类在一起。
本研究表明，华夏铂金系统中包含的 23 个常染色体 STR 基因座具有高度多态性，适合该人群的个人法医鉴定和亲子关系测试。
