Cancer Biomark. 2020;29(1):89-99. doi: 10.3233/CBM-191226.
The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is the protein product of at least one splice variant of each gene contained a Marvel (MAL and related proteins for vesicle trafficking and membrane link) domain, involved in a variety of cellular processes and the pathogenesis of diseases, including tumorigenesis. However, the diverse expression patterns and prognostic values of eight CMTMs have yet to be elucidated.
We analyzed the expressions and impacts on survival of different CMTM factors in BC patients to determine their potential diagnosis and prognosis values in BC.
In the current study, we examined the transcriptional and survival data of CMTMs in patients with breast carcinoma (BC) from ONCOMINE, GEPIA, Kaplan-Meier Plotter, and cBioPortal databases.
It was found that CMTM5/7 were down-regulated, whereas CMTM1/6 were up-regulated in BC patients compared with the normal tissues. In survival analyses through the Kaplan-Meier plotter database, increased mRNA expressions of CMTM5/6/7 and decreased mRNA expression of CMTM4 were associated with better relapse-free survival (RFS) of BC patients.
These data provided CMTM5/7 as new biomarker and prognostic factors in BC.
CKLF 样 MARVEL 跨膜结构域包含家族（CMTM）是至少一个 Marvel（MAL 和与囊泡转运和膜连接相关的蛋白）结构域所含每个基因的剪接变异体的蛋白产物，参与多种细胞过程和疾病的发病机制，包括肿瘤发生。然而，八个 CMTM 的不同表达模式和预后价值尚未阐明。
我们分析了 BC 患者中不同 CMTM 因子的表达及其对生存的影响，以确定它们在 BC 中的潜在诊断和预后价值。
在本研究中，我们通过 ONCOMINE、GEPIA、Kaplan-Meier Plotter 和 cBioPortal 数据库检查了乳腺癌（BC）患者的 CMTM 转录和生存数据。
与正常组织相比，发现 CMTM5/7 在 BC 患者中下调，而 CMTM1/6 上调。通过 Kaplan-Meier plotter 数据库的生存分析发现，CMTM5/6/7 的 mRNA 表达增加和 CMTM4 的 mRNA 表达降低与 BC 患者更好的无复发生存（RFS）相关。
这些数据为 BC 提供了 CMTM5/7 作为新的生物标志物和预后因素。
