Graham D Y
Veterans Administration Medical Center, Houston, TX 77030.
Mayo Clin Proc. 1988 Dec;63(12):1258-60. doi: 10.1016/s0025-6196(12)65415-9.
Occurrence of C. pylori infection of mucosa outside of the stomach might provide an ideal opportunity to examine C. pylori-mucosal interactions apart from the effects of acid and pepsin. Techniques previously used to examine Barrett's epithelium (for example, special mucin stains or scanning and transmission electron microscopy) might be particularly useful for exploration of new associations and formulation of new hypotheses. Whether C. pylori has a role in development of Barrett's ulcer or adenocarcinoma as a complication of Barrett's esophagus remains unanswered. Most of the current data about C. pylori are primarily observational; further studies are needed for clarification of important microbegut interactions.
胃外黏膜幽门螺杆菌感染的发生可能为研究幽门螺杆菌与黏膜的相互作用提供了一个理想的机会，可排除胃酸和胃蛋白酶的影响。以前用于检查巴雷特上皮的技术（例如，特殊黏液染色或扫描及透射电子显微镜检查）可能对探索新的关联和形成新的假设特别有用。幽门螺杆菌在巴雷特溃疡或腺癌（作为巴雷特食管的并发症）的发生中是否起作用仍未得到解答。目前关于幽门螺杆菌的大多数数据主要是观察性的；需要进一步研究以阐明重要的微生物与肠道的相互作用。
