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超高分子量聚乙烯表面的坚固、自消毒抗菌铜涂层:抗菌人工关节材料的可行性初探。

A rugged, self-sterilizing antimicrobial copper coating on ultra-high molecular weight polyethylene: a preliminary study on the feasibility of an antimicrobial prosthetic joint material.

机构信息

Department of Chemistry, University College London, 20 Gordon Street, London, WC1E 0AJ, UK.

Department of Chemical Engineering, University College London, Torrington Place, WC1E 7JE, UK.

出版信息

J Mater Chem B. 2019 May 22;7(20):3310-3318. doi: 10.1039/c9tb00440h.

Abstract

We report here for the first time how the combination of a precursor solution and low temperature (170 °C) aerosol assisted chemical vapour deposition were used to bond a copper coating to ultra-high molecular weight polyethylene (UHMWPE) and promote robustness. This metallic thin film remained intact on the UHMWPE substrate after the Scotch tape test and showed notable wear-resistance after 10 cycles of sand paper-abrasion. Antimicrobial assays against both Escherichia coli and Staphylococcus aureus revealed potent dark bactericidal activity with 99.999% reduction in bacterial number within 15 minutes. These results suggest that the modified UHMWPE could be a potential candidate for antimicrobial plastics and in the long term may find application in prosthetic joint applications.

摘要

我们首次报告了如何通过前驱溶液和低温(170°C)气溶胶辅助化学气相沉积相结合,将铜涂层粘结到超高分子量聚乙烯(UHMWPE)上并提高其稳定性。经过 Scotch 胶带测试后,这种金属薄膜仍然完好无损地附着在 UHMWPE 基底上,并且在经过 10 次砂纸磨损循环后表现出显著的耐磨性。针对大肠杆菌和金黄色葡萄球菌的抗菌试验表明,这种材料具有很强的暗杀菌活性,在 15 分钟内可将细菌数量减少 99.999%。这些结果表明,改性 UHMWPE 可能成为抗菌塑料的潜在候选材料,从长远来看,它可能在假肢关节应用中得到应用。

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