Bai Rushui, Peng Liying, Sun Qiannan, Zhang Yunfan, Zhang Lingyun, Wei Yan, Han Bing
Department of Orthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, China.
Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, China.
Materials (Basel). 2020 Oct 15;13(20):4594. doi: 10.3390/ma13204594.
The oral cavity harbors complex microbial communities, which leads to biomaterial-associated infections (BAI) during dental and orthopedic treatments. Conventional antibiotic treatments have met great challenges recently due to the increasing emergency of drug-resistant bacteria. To tackle this clinical issue, antibacterial surface treatments, containing surface modification and coatings, of dental and orthopedic materials have become an area of intensive interest now. Among various antibacterial agents used in surface treatments, metallic agents possess unique properties, mainly including broad-spectrum antibacterial properties, low potential to develop bacterial resistance, relative biocompatibility, and chemical stability. Therefore, this review mainly focuses on underlying antibacterial applications and the mechanisms of metallic agents in dentistry and orthopedics. An overview of the present review indicates that much work remains to be done to deepen the understanding of antibacterial mechanisms and potential side-effects of metallic agents.
口腔中存在复杂的微生物群落，这在牙科和骨科治疗过程中会导致生物材料相关感染（BAI）。由于耐药菌的日益出现，传统的抗生素治疗最近面临着巨大挑战。为了解决这一临床问题，牙科和骨科材料的抗菌表面处理，包括表面改性和涂层，已成为目前备受关注的领域。在表面处理中使用的各种抗菌剂中，金属剂具有独特的性能，主要包括广谱抗菌性能、产生细菌耐药性的可能性低、相对生物相容性和化学稳定性。因此，本综述主要关注金属剂在牙科和骨科中的潜在抗菌应用及其作用机制。对本综述的概述表明，在加深对金属剂抗菌机制和潜在副作用的理解方面仍有许多工作要做。
