Rheumatology, Hospital General de Ontinyent, Ontinyent, ValenciaSpain.
Rheumatology, Complejo Hospitalario Universitario de Vigo, Grupo IRIDIS, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, PontevedraSpain.
Rheumatology (Oxford). 2020 Sep 1;59(9):2556-2562. doi: 10.1093/rheumatology/kez668.
Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by the Spanish Society of Rheumatology, the prevalence estimate of SLE in the general adult population in Spain has been updated and its association with sociodemographic, anthropometric and lifestyle variables has been explored.
Population-based multicentre cross-sectional study, with multistage stratified and cluster random sampling. Participants were contacted by telephone to carry out a questionnaire for the screening of SLE. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated considering age, sex and geographic origin. Multivariate logistic regression models were defined to analyse which sociodemographic, anthropometric and lifestyle variables included in the telephone questionnaire were associated with the presence of SLE.
4916 subjects aged 20 years or over were included. 16.52% (812/4916) had a positive screening result for SLE. 12 cases of SLE were detected. The estimated prevalence was 0.21% (95% CI: 0.11, 0.40). SLE was more prevalent in the rural municipalities, with an odds ratio (OR) = 4.041 (95% CI: 1.216, 13.424).
The estimated prevalence of SLE in Spain is higher than that described in most international epidemiological studies, but lower than that observed in ethnic minorities in the United States or the United Kingdom.
SLE 的患病率因研究设计、地理区域和种族的不同而有所差异。有关西班牙 SLE 患病率的数据较为匮乏。在由西班牙风湿病学会发起的 EPISER2016 研究中，更新了西班牙普通成年人群中 SLE 的患病率估计值，并探讨了其与社会人口统计学、人体测量学和生活方式变量的相关性。
这是一项基于人群的多中心横断面研究，采用多阶段分层和聚类随机抽样。通过电话联系参与者，进行 SLE 筛查问卷。调查风湿病学家评估阳性结果（查阅病历和/或电话访谈，如果需要则进行电话访谈）以确认诊断。为了计算患病率及其 95%置信区间，考虑了样本设计，并根据年龄、性别和原籍地计算了加权。定义了多变量逻辑回归模型，以分析电话问卷中包含的哪些社会人口统计学、人体测量学和生活方式变量与 SLE 的存在相关。
共纳入 4916 名年龄在 20 岁及以上的受试者。SLE 筛查阳性结果的比例为 16.52%（812/4916）。检出 SLE 病例 12 例。估计患病率为 0.21%（95%CI：0.11，0.40）。SLE 在农村自治市更为普遍，优势比（OR）=4.041（95%CI：1.216，13.424）。
西班牙 SLE 的估计患病率高于大多数国际流行病学研究中描述的患病率，但低于美国或英国少数民族中观察到的患病率。
