Wu Xia-qiu, Peng Jin, Li Guo-qin, Su Hui-ping, Liu Guang-xia, Liu Bao-yan
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Department of Respiration, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Chin J Integr Med. 2016 Apr;22(4):284-92. doi: 10.1007/s11655-016-2497-y. Epub 2016 Apr 9.
To examine the variations in the prevalence of skin reactions and the association between skin reactions and efficacy of summer acupoint application treatment (SAAT) on chronic pulmonary disease (CPD).
A total of 2,038 patients with CPD were enrolled at 3 independent hospitals (defined as Groups A, B and C, respectively) in China. All patients were treated by SAAT, as applying a herbal paste onto the acupoints of Fengmen (BL 12) and Feishu (BL 13) on the dog days of summer, according to the lunar calendar, in 2008. Ten days after treatment, skin reaction data (no reaction, itching, stinging, blistering, and infection) were obtained via face-to-face interviews. Patients were retreated in the same hospital one year later, thereby allowing doctors to assess treatment efficacy based on the patients' symptoms, the severity of the spirometric abnormalities, and the concomitant medications used.
A large number of patients (85.3%) displayed reactive symptoms; however, the marked associations between reactive symptoms and age or gender were not observed. An increased number of patients from Group B (99.3%) and Group C (76.5%) displayed reactive symptoms due to the increased mass of crude Semen Sinapis Albae. The effective rate of SAAT was as high as 90.4% for patients of Group B, which was followed by Group A (70.9%) and Group C (42.2%). Using stratified analyses, a convincing association between reactive symptoms and therapeutic efficacy was observed for patients with asthma [itching: odds ratio (OR)=2.17, 95% confidence interval (CI): 1.49 to 3.14; blistering: OR=0.43, 95% CI: 0.25 to 0.73; and no reaction: OR=0.56, 95% CI: 0.35 to 0.90]. However, the same tendency was not observed for patients with chronic bronchitis and chronic obstructive pulmonary disease.
SAAT can induce very mild skin reactions for patients with CPD, among which patients with asthma displayed a strong association between skin reactions and therapeutic efficacy. The skin reactions may be induced by the crude Semen Sinapis Albae.
探讨慢性肺疾病（CPD）患者夏季穴位敷贴治疗（SAAT）皮肤反应发生率的变化以及皮肤反应与疗效之间的关联。
在中国3家独立医院（分别定义为A组、B组和C组）共纳入2038例CPD患者。所有患者均接受SAAT治疗，即在2008年农历三伏天期间，将中药膏剂敷贴于风门（BL 12）和肺俞（BL 13）穴位。治疗10天后，通过面对面访谈获取皮肤反应数据（无反应、瘙痒、刺痛、水疱和感染）。一年后，患者在同一家医院接受再次治疗，从而使医生能够根据患者的症状、肺功能异常的严重程度以及使用的伴随药物来评估治疗效果。
大量患者（85.3%）出现反应性症状；然而，未观察到反应性症状与年龄或性别之间存在明显关联。由于白芥子用量增加，B组（99.3%）和C组（76.5%）出现反应性症状的患者数量增加。B组患者SAAT的有效率高达90.4%，其次是A组（70.9%）和C组（42.2%）。采用分层分析，观察到哮喘患者的反应性症状与治疗效果之间存在令人信服的关联[瘙痒：比值比（OR）=2.17，95%置信区间（CI）：1.49至3.14；水疱：OR=0.43，95%CI：0.25至0.73；无反应：OR=0.56，95%CI：0.35至0.90]。然而，慢性支气管炎和慢性阻塞性肺疾病患者未观察到相同趋势。
SAAT可使CPD患者出现非常轻微的皮肤反应，其中哮喘患者的皮肤反应与治疗效果之间存在较强关联。皮肤反应可能由白芥子引起。
