Department of Food and Nutritional Sciences, Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, UK.
Proc Nutr Soc. 2020 May;79(2):194-204. doi: 10.1017/S0029665119001186. Epub 2020 Jan 31.
Several studies on gene-diet interactions (nutrigenetics) have been performed in western populations; however, there are only a few studies to date in lower middle-income countries (LMIC). A large-scale collaborative project called gene-nutrient interactions (GeNuIne) Collaboration, the main objective of which is to investigate the effect of GeNuIne on cardiometabolic traits using population-based studies from various ethnic groups, has been initiated at the University of Reading, UK. While South Asians with higher genetic risk score (GRS) showed a higher risk of obesity in response to a high-carbohydrate diet, South East and Western Asian populations with higher GRS showed an increased risk of central obesity in response to a high-protein diet. The paper also provides a summary of other gene-diet interaction analyses that were performed in LMIC as part of this collaborative project and gives an overview of how these nutrigenetic findings can be translated to personalised and public health approaches for the prevention of cardiometabolic diseases such as obesity, type 2 diabetes and CVD.
几项关于基因-饮食相互作用（营养遗传学）的研究已经在西方人群中进行；然而，迄今为止，中低收入国家（LMIC）只有少数研究。一个名为基因-营养素相互作用（GeNuIne）合作的大型合作项目已经在英国雷丁大学启动，其主要目标是使用来自不同种族的基于人群的研究来研究 GeNuIne 对心脏代谢特征的影响。南亚人具有较高的遗传风险评分（GRS），在高碳水化合物饮食下表现出更高的肥胖风险，而具有较高 GRS 的东南亚和西亚人群在高蛋白质饮食下表现出中心性肥胖的风险增加。本文还总结了作为该合作项目一部分在 LMIC 进行的其他基因-饮食相互作用分析，并概述了如何将这些营养遗传学发现转化为预防肥胖、2 型糖尿病和 CVD 等心脏代谢疾病的个性化和公共卫生方法。
