Kao Fu-Cheng, Chiu Ping-Yeh, Tsai Tsung-Ting, Lin Zong-Hong
Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Sci Technol Adv Mater. 2019 Nov 19;20(1):1103-1117. doi: 10.1080/14686996.2019.1693880. eCollection 2019.
Bone is a complex organ possessing both physicomechanical and bioelectrochemical properties. In the view of Wolff's Law, bone can respond to mechanical loading and is subsequently reinforced in the areas of stress. Piezoelectricity is one of several mechanical responses of the bone matrix that allows osteocytes, osteoblasts, osteoclasts, and osteoprogenitors to react to changes in their environment. The present review details how osteocytes convert external mechanical stimuli into internal bioelectrical signals and the induction of intercellular cytokines from the standpoint of piezoelectricity. In addition, this review introduces piezoelectric and triboelectric materials used as self-powered electrical generators to promote osteogenic proliferation and differentiation due to their electromechanical properties, which could promote the development of promising applications in tissue engineering and bone regeneration.
骨骼是一种具有物理力学和生物电化学特性的复杂器官。根据沃尔夫定律，骨骼能够对机械负荷做出反应，并随后在应力区域得到强化。压电性是骨基质的几种机械反应之一，它使骨细胞、成骨细胞、破骨细胞和骨祖细胞能够对其环境变化做出反应。本综述从压电性的角度详细阐述了骨细胞如何将外部机械刺激转化为内部生物电信号以及细胞间细胞因子的诱导。此外，本综述还介绍了用作自供电发电机的压电和摩擦电材料，由于其机电特性，这些材料可促进成骨细胞的增殖和分化，这可能会推动组织工程和骨再生领域有前景的应用发展。
