National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Palaj, Gandhinagar 382355, India.
National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Palaj, Gandhinagar 382355, India.
Med Hypotheses. 2017 Oct;108:10-16. doi: 10.1016/j.mehy.2017.07.021. Epub 2017 Jul 25.
Bone and cartilage are major weight-bearing connective tissues in human and possesses utmost vulnerability for degeneration. The potential causes are mechanical trauma, cancer and disease condition like osteoarthritis and osteoporosis, etc. The regeneration/repair is a challenging, since their complex structures and activities. Current treatment options comprise of auto graft, allograft, artificial bone substituent, autologous chondrocyte implantation, mosaicplasty, marrow stimulation and tissue engineering. Were incompetent to overcome the problem like abandoned growth factor degradation, indistinct growth factor dose and lack of integrity and mechanical properties in regenerated tissues. Present, paper focuses on the novel hypothesis for regeneration of bone and cartilage by using piezoelectric smart property of scaffold material.
骨和软骨是人体主要的承重结缔组织，极易发生退行性病变。潜在的原因有机械创伤、癌症和骨关节炎、骨质疏松症等疾病状况。由于其复杂的结构和功能，再生/修复是一个具有挑战性的问题。目前的治疗选择包括自体移植物、同种异体移植物、人工骨替代物、自体软骨细胞移植、马赛克plasty、骨髓刺激和组织工程。它们无法克服生长因子降解、生长因子剂量不明确以及再生组织完整性和机械性能缺乏等问题。目前，本文专注于利用支架材料的压电智能特性来再生骨和软骨的新假说。
