Gray F, Gherardi R, Keohane C, Favolini M, Sobel A, Poirier J
Département de Pathologie (Neuropathologie), Hôpital Henri Mondor, Créteil, France.
Neuropathol Appl Neurobiol. 1988 Sep-Oct;14(5):365-80. doi: 10.1111/j.1365-2990.1988.tb01139.x.
The central nervous system was examined in 40 AIDS patients who died between August 1982 and 1987. The cases included two children born to intravenous drug abusers and 38 male adults. The brains of eight patients who had no clinical or radiological evidence of central nervous system involvement showed non-specific changes which included microglial nodules, perivascular mononuclear cuffs, mineralization of blood vessels and granular ependymitis. In 32 brains from patients with neurological symptoms, toxoplasmosis was the most frequent finding (19 cases) manifested by multifocal, necrotic lesions or a diffuse pseudo-encephalitic process. Other opportunistic infections included cytomegalovirus (eight cases), progressive multifocal leucoencephalopathy (two cases), cryptococcosis (one case), aspergillosis (one case), multiple bacterial microabscesses (one case) and Mycobacterium avium intracellulare (one case). Two patients had cerebral lymphoma. Subacute encephalitis with white matter lesions and multinucleated giant cells characteristic of HIV infection was present in 15 cases. Various combinations of all these infections were encountered in the same brain, sometimes in the same area and, occasionally, in the same cell.
对1982年8月至1987年间死亡的40例艾滋病患者的中枢神经系统进行了检查。病例包括2名静脉吸毒者的子女和38名成年男性。8例无中枢神经系统受累临床或影像学证据的患者大脑显示非特异性改变，包括小胶质结节、血管周围单核细胞套袖、血管钙化和颗粒性室管膜炎。在32例有神经症状患者的大脑中，弓形虫病是最常见的发现（19例），表现为多灶性坏死性病变或弥漫性假脑炎过程。其他机会性感染包括巨细胞病毒（8例）、进行性多灶性白质脑病（2例）、隐球菌病（1例）、曲霉菌病（1例）、多发性细菌性微脓肿（1例）和鸟分枝杆菌胞内菌（1例）。2例患者患有脑淋巴瘤。15例患者存在具有HIV感染特征的伴有白质病变和多核巨细胞的亚急性脑炎。在同一大脑中，有时在同一区域，偶尔在同一细胞内，会遇到所有这些感染的各种组合。
