Negahdary M, Sattarahmady N, Heli H
Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Clin Chim Acta. 2020 May;504:43-55. doi: 10.1016/j.cca.2020.01.028. Epub 2020 Jan 28.
Prostate cancer is one of the most dangerous and deadly cancers in elderly men. Early diagnosis using prostate-specific antigen (PSA) facilitates disease detection, management and treatment. Biosensors have recently been used as sensitive, selective, inexpensive and rapid diagnostic tools for PSA detection. In this review, a variety of PSA biosensors such as aptasensors, peptisensors and immunesensors are highlighted. These use aptamers, peptides and antibodies in the biorecognition element, respectively, and can detect PSA with very high sensitivity via electrochemical, electrochemiluminescence, fluorescence and surface-enhanced Raman spectroscopy. To improve the sensitivity of most of these PSA biosensors, different nanostructured materials have played a critical role.
前列腺癌是老年男性中最危险、最致命的癌症之一。使用前列腺特异性抗原（PSA）进行早期诊断有助于疾病的检测、管理和治疗。生物传感器最近已被用作检测PSA的灵敏、选择性强、廉价且快速的诊断工具。在本综述中，重点介绍了多种PSA生物传感器，如适体传感器、肽传感器和免疫传感器。这些传感器分别在生物识别元件中使用适体、肽和抗体，并可通过电化学、电化学发光、荧光和表面增强拉曼光谱以非常高的灵敏度检测PSA。为提高大多数此类PSA生物传感器的灵敏度，不同的纳米结构材料发挥了关键作用。
