Gupta Uttio, Gupta Yashdeep, Jose Divya, Mani Kalaivani, Jyotsna Viveka P, Sharma Gautam, Tandon Nikhil
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.
Diabetes Ther. 2020 Mar;11(3):667-679. doi: 10.1007/s13300-020-00769-2. Epub 2020 Jan 31.
This study was designed to investigate the effectiveness of a video-based lifestyle education program (VBLEP) in improving glycemic control in people with type 2 diabetes mellitus compared with usual care.
Patients on stable oral glucose-lowering agents for at least 3 months and HbA1c 7.5-10% were randomized in a 1:1 ratio. Primary outcome measure was the difference in change in mean HbA1c between groups.
The participants (n = 81) had mean (± SD) age of 50.1 (± 9.4) years and HbA1c of 8.5 ± 0.7% (68.87 ± 7.56 mmol/mol). The follow-up data were available in 96% (78/81) of participants. Of 40 participants, 36 (90%) attended ≥ 75% (≥ 3 out of 4) of the sessions in the VBLEP. In the intention-to-treat analysis, a significant reduction [0.6% 95% CI (0.1, 1.1), p = 0.013] in HbA1c was seen in the VBLEP group compared with usual care. A ≥ 1% reduction in HbA1c was observed in 39.5% of participants in the VBLEP compared with 15% in the usual care arm. However, a ≥ 0.5% reduction in HbA1c was observed in 65.8% of participants in the VBLEP compared with 37.5% in the usual care arm (p = 0.012). There was a significant change in weight and body mass index in the VBLEP group compared with usual care. The participants who were employed, had a family history of diabetes, had no diabetes-related complications, and were in the VBLEP group had higher odds of having a favorable HbA1c reduction (≥ 0.5%, combined analysis both groups) from baseline.
The VBLEP demonstrated a significant and clinically relevant HbA1c reduction compared with usual care. A simple VBLEP, when delivered in an interactive manner, can aid in improving glycemic outcomes in the Indian population.
CTRI/2017/05/008564.
本研究旨在调查与常规护理相比，基于视频的生活方式教育项目（VBLEP）在改善2型糖尿病患者血糖控制方面的有效性。
将服用稳定口服降糖药至少3个月且糖化血红蛋白（HbA1c）在7.5%-10%之间的患者按1:1比例随机分组。主要结局指标是两组间平均HbA1c变化的差异。
参与者（n = 81）的平均（±标准差）年龄为50.1（±9.4）岁，HbA1c为8.5±0.7%（68.87±7.56 mmol/mol）。96%（78/81）的参与者有随访数据。在40名参与者中，36名（90%）参加了VBLEP中≥75%（4次中的≥3次）的课程。在意向性分析中，与常规护理相比，VBLEP组的HbA1c有显著降低[0.6%，95%置信区间（0.1，1.1），p = 0.013]。与常规护理组的15%相比，VBLEP组39.5%的参与者HbA1c降低≥1%。然而，与常规护理组的37.5%相比，VBLEP组65.8%的参与者HbA1c降低≥0.5%（p = 0.012）。与常规护理相比，VBLEP组的体重和体重指数有显著变化。受雇、有糖尿病家族史、无糖尿病相关并发症且在VBLEP组的参与者从基线开始HbA1c降低≥0.5%（两组合并分析）的几率更高。
与常规护理相比，VBLEP显示出显著且具有临床意义的HbA1c降低。一个简单的VBLEP以互动方式实施时，有助于改善印度人群的血糖结局。
CTRI/2017/05/008564。
