R.E. van Bentum, MD, T.R. Rusman, MSc, I.E. van der Horst-Bruinsma, MD, PhD, Professor, Department of Rheumatology, Amsterdam University Medical Centre, Vrije Universiteit, Amsterdam, the Netherlands.
S.E. Ibáñez Vodnizza, MD, M.P. Poblete de la Fuente, MD, F. Valenzuela Aldridge, MD, O. Valenzuela Letelier, MD, Department of Rheumatology, Clínica Alemana - UDD Medicine Faculty, Santiago, Chile.
J Rheumatol. 2020 Oct 1;47(10):1475-1482. doi: 10.3899/jrheum.191063. Epub 2020 Feb 1.
Physical function in patients with axial spondyloarthritis (axSpA) is currently evaluated through questionnaires. The Ankylosing Spondylitis Performance Index (ASPI) is a performance-based measure for physical functioning, which has been validated in Dutch patients with radiographic (r-) axSpA. The interrater reliability has not yet been determined. To our knowledge, this study is the first to evaluate the validity, reliability, and feasibility of the ASPI in another patient population, including both r- and nonradiographic (nr-) axSpA patients.
Patients with axSpA were recruited from rheumatology clinics in Santiago, Chile. Dutch instructions were translated to Spanish by a forward-backward procedure. Study visits were performed at baseline and 1-4 weeks later. Four ASPI observers were involved, measuring the performance times of the 3 ASPI tests. Validity was assessed through a patient questionnaire (numeric rating scale 0-10: ≥ 6 sufficient). For reliability, intraclass correlation coefficients (ICC) were calculated (with 95% CI). Correlations between the ASPI and disease variables were tested with regression analyses.
Sixty-eight patients were included (57% male, 52% r-axSpA). All patients understood the Spanish instructions and considered the ASPI to reach its aim (84%) and representativeness (85%) for physical functioning. The overall interrater (n = 62) and test-retest (n = 39) reliability (ICC) of the 3 tests combined were 0.93 (0.88-0.96) and 0.94 (0.87-0.97), respectively. Eighty-two percent of the patients completed all tests and 94% finished in < 15 min (feasibility).
This study demonstrated a high validity and feasibility in an entirely different population, with both r-axSpA and nr-axSpA. The interrater and test-retest reliability was excellent. The ASPI instructions are now available for Spanish-speaking patients.
目前,评估患有中轴型脊柱关节炎(axSpA)患者的身体功能是通过问卷调查进行的。强直性脊柱炎功能指数(ASPI)是一种用于身体功能的基于表现的测量方法,已在荷兰放射学(r-)axSpA 患者中得到验证。其观察者间信度尚未确定。据我们所知,这项研究首次评估了 ASPI 在另一个患者群体中的有效性、可靠性和可行性,该群体包括 r- 和非放射学(nr-)axSpA 患者。
从智利圣地亚哥的风湿病诊所招募 axSpA 患者。荷兰说明书通过正向-反向翻译程序翻译成西班牙语。研究访视在基线时和 1-4 周后进行。涉及 4 名 ASPI 观察者,测量 3 项 ASPI 测试的表现时间。通过患者问卷(数值评定量表 0-10:≥6 为足够)评估有效性。为了评估可靠性,计算了组内相关系数(ICC)(95%置信区间)。使用回归分析测试 ASPI 与疾病变量之间的相关性。
共纳入 68 例患者(57%为男性,52%为 r-axSpA)。所有患者均理解西班牙语说明,并认为 ASPI 达到了其身体功能的目的(84%)和代表性(85%)。3 项测试综合的观察者间(n=62)和测试-重测(n=39)可靠性(ICC)分别为 0.93(0.88-0.96)和 0.94(0.87-0.97)。82%的患者完成了所有测试,94%的患者在<15 分钟内完成(可行性)。
这项研究在一个完全不同的人群中,包括 r-axSpA 和 nr-axSpA,显示了较高的有效性和可行性。观察者间和测试-重测的可靠性非常好。现在为讲西班牙语的患者提供了 ASPI 说明书。