抗细菌性鱼类疾病的活疫苗：综述
Live vaccines against bacterial fish diseases: A review.
作者信息
Mohd-Aris Aslizah, Muhamad-Sofie Mohd Hafiz Ngoo, Zamri-Saad Mohd, Daud Hassan Mohd, Ina-Salwany Md Yasin
机构信息
Department of Biology, School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kampus Kuala Pilah, Malaysia.
Laboratory of Marine Biotechnology, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia.
出版信息
Vet World. 2019 Nov;12(11):1806-1815. doi: 10.14202/vetworld.2019.1806-1815. Epub 2019 Nov 21.
Fish diseases are often caused either by bacteria, viruses, fungi, parasites, or a combination of these pathogens. Of these, bacterial fish diseases are considered to be a major problem in the aquaculture industry. Hence, the prevention of such diseases by proper vaccination is one of the integral strategies in fish health management, aimed at reducing the fish mortality rate in the aquaculture farms. Vaccination offers an effective yet low-cost solution to combat the risk of disease in fish farming. An appropriate vaccination regime to prevent bacterial diseases offers a solution against the harmful effects of antibiotic applications. This review discusses the role of live-attenuated vaccine in controlling bacterial diseases and the development of such vaccines and their vaccination strategy. The current achievements and potential applications of live-attenuated and combined vaccines are also highlighted. Vaccine development is concluded to be a demanding process, as it must satisfy the requirements of the aquaculture industry.
鱼类疾病通常由细菌、病毒、真菌、寄生虫或这些病原体的组合引起。其中，细菌性鱼类疾病被认为是水产养殖业的一个主要问题。因此，通过适当接种疫苗来预防此类疾病是鱼类健康管理的重要策略之一，旨在降低水产养殖场的鱼类死亡率。接种疫苗为应对养鱼业疾病风险提供了一种有效且低成本的解决方案。预防细菌性疾病的适当接种方案提供了一种对抗抗生素应用有害影响的解决方案。本综述讨论了减毒活疫苗在控制细菌性疾病中的作用以及此类疫苗的开发及其接种策略。还强调了减毒活疫苗和联合疫苗的当前成就和潜在应用。疫苗开发被认为是一个艰巨的过程，因为它必须满足水产养殖业的要求。
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