He Weiwei, Yu Jintao, Sun Yu, Kong Weijia
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Aging Dis. 2020 Feb 1;11(1):191-199. doi: 10.14336/AD.2019.0723. eCollection 2020 Feb.
Acoustic trauma is an important physical factor leading to cochlear damage and hearing impairments. Inflammation responds to this kind of cochlear damage stress. Macrophages, the major innate immune cells in the cochlea, are important drivers of inflammatory and tissue repair responses after cochlear injury. Recently, studies have shown that after noise exposure, the distribution, phenotype, and the number of cochlear macrophages have significantly changed, and the local environmental factors that shape macrophage differentiation and behavior are also drastically altered. However, the exact role of these immune cells in the cochlea after acoustic injury remains unknown. Here we review the properties of cochlear macrophages both under steady-state conditions and non-homeostatic conditions after cochlear acoustic injury and discuss their potential role in noise-exposed cochlea.
声学创伤是导致耳蜗损伤和听力障碍的重要物理因素。炎症是对这种耳蜗损伤应激的反应。巨噬细胞是耳蜗中的主要固有免疫细胞，是耳蜗损伤后炎症和组织修复反应的重要驱动因素。最近的研究表明，噪声暴露后，耳蜗巨噬细胞的分布、表型和数量发生了显著变化，影响巨噬细胞分化和行为的局部环境因素也发生了巨大改变。然而，这些免疫细胞在声学损伤后耳蜗中的具体作用仍不清楚。在此，我们综述了耳蜗声学损伤后稳态条件和非稳态条件下耳蜗巨噬细胞的特性，并讨论了它们在噪声暴露耳蜗中的潜在作用。
