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1.3微米处的稳定多兆赫兹环形光学相干断层扫描技术

Stable multi-megahertz circular-ranging optical coherence tomography at 1.3 µm.

作者信息

Lippok Norman, Bouma Brett E, Vakoc Benjamin J

机构信息

Harvard Medical School, Boston, MA 02115, USA.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

出版信息

Biomed Opt Express. 2019 Dec 9;11(1):174-185. doi: 10.1364/BOE.11.000174. eCollection 2020 Jan 1.

Abstract

In Fourier-domain optical coherence tomography (OCT), the finite bandwidth of the acquisition electronics constrains the depth range and speed of the system. Circular-ranging (CR) OCT methods use optical-domain compression to surpass this limit. However, the CR-OCT system architectures of prior reports were limited by poor stability and were confined to the 1.55 µm wavelength range. In this work, we describe a novel CR-OCT architecture that is free from these limitations. To ensure stable operation, temperature sensitive optical modules within the system were replaced; the kilometer-length fiber spools used in the stretched-pulse mode-locked (SPML) laser was eliminated in favor of a single 10 meter, continuously chirped fiber Bragg grating, and the interferometer's passive optical quadrature demodulation circuit was replaced by an active technique using a lithium niobate phase modulator. For improved imaging penetration in biological tissues, the system operating wavelength was shifted to a center wavelength of 1.29 µm by leveraging the wavelength flexibility intrinsic to CFBG-based dispersive fibers. These improvements were achieved while maintaining a broad (100 nm) optical bandwidth, a long 4 cm imaging range, and a high 7.6 MHz A-line rate. By enhancing stability, simplifying overall system design, and operating at 1.3 µm, this CR-OCT architecture will allow a broader exploration of CR-OCT in both medical and non-medical applications.

摘要

在傅里叶域光学相干断层扫描(OCT)中,采集电子设备的有限带宽限制了系统的深度范围和速度。圆扫描(CR)OCT方法利用光域压缩来突破这一限制。然而,先前报道的CR-OCT系统架构受到稳定性差的限制,并且局限于1.55 µm波长范围。在这项工作中,我们描述了一种没有这些限制的新型CR-OCT架构。为确保稳定运行,更换了系统内对温度敏感的光学模块;摒弃了拉伸脉冲锁模(SPML)激光器中使用的千米长光纤卷轴,转而采用一根10米长的连续啁啾光纤布拉格光栅,并且干涉仪的无源光学正交解调电路被一种使用铌酸锂相位调制器的有源技术所取代。为提高在生物组织中的成像穿透深度,利用基于啁啾光纤布拉格光栅(CFBG)的色散光纤固有的波长灵活性,将系统工作波长移至1.29 µm的中心波长。在保持宽(100 nm)光学带宽、4 cm长的成像范围和7.6 MHz高A线速率的同时实现了这些改进。通过提高稳定性、简化整体系统设计并在1.3 µm波长下运行,这种CR-OCT架构将允许在医学和非医学应用中更广泛地探索CR-OCT。

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