Siddiqui Meena, Nam Ahhyun S, Tozburun Serhat, Lippok Norman, Blatter Cedric, Vakoc Benjamin J
Harvard Medical School, Boston, Massachusetts 02115, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Nat Photonics. 2018;12:111-116. doi: 10.1038/s41566-017-0088-x. Epub 2018 Jan 29.
Existing three-dimensional optical imaging methods excel in controlled environments but are difficult to deploy over large, irregular and dynamic fields. This has limited imaging in areas such as material inspection and medicine. To better address these applications, we developed methods in optical coherence tomography (OCT) to efficiently interrogate sparse scattering fields, i.e., those in which most locations (voxels) do not generate meaningful signal. Frequency comb sources are used to superimpose reflected signals from equispaced locations through optical subsampling. This results in circular ranging, and reduces the number of measurements required to interrogate large volumetric fields. As a result, signal acquisition barriers that have limited speed and field in OCT are avoided. With a new ultrafast, time-stretched frequency comb laser design operating with 7.6 MHz to 18.9 MHz repetition rates, we achieved imaging of multi-cm fields at up to 7.5 volumes per second.
现有的三维光学成像方法在可控环境中表现出色,但难以在大型、不规则和动态区域中应用。这限制了材料检测和医学等领域的成像。为了更好地解决这些应用问题,我们开发了光学相干断层扫描(OCT)方法,以有效地探测稀疏散射场,即大多数位置(体素)不会产生有意义信号的场。频率梳源用于通过光学子采样叠加来自等距位置的反射信号。这导致了圆形测距,并减少了探测大体积场所需的测量次数。结果,避免了在光学相干断层扫描中限制速度和视野的信号采集障碍。通过一种新型超快、时间拉伸频率梳激光器设计,其重复频率为7.6兆赫兹至18.9兆赫兹,我们实现了每秒高达7.5个体积的多厘米场成像。