Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Dermatology Unit, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Int J Environ Res Public Health. 2020 Jan 29;17(3):839. doi: 10.3390/ijerph17030839.
Primary cutaneous anaplastic large cell lymphoma (pcALCL) is part of a spectrum of cutaneous CD30+ lymphoproliferative disease that also includes lymphomatoid papulosis. It often occurs in elderly patients, presenting at a median age of 60 years, although it may occur at any age. It is a CD30+ T-cell neoplasm composed of large cells with anaplastic, pleomorphic, or immunoblastic morphology, with exclusively cutaneous onset and localization. The clinical course of pcALCL is predominantly indolent. Most elderly patients with lymphoma tend to have a sedentary lifestyle, which has a negative effect on their quality of life (QoL) and survival. Several studies indicate that exercise has a positive impact on QoL because it reduces peak oxygen consumption, improves physical capacity, increases self-esteem, reduces accumulated stress, and promotes relaxation. Therefore, particularly in indolent lymphomas, it is necessary to indicate a program of physical activity to be practiced systematically. Complete surgical excision and local radiotherapy are the first line gold standard in pcALCL with a solitary lesion.
原发性皮肤间变性大细胞淋巴瘤（pcALCL）是皮肤 CD30+淋巴增生性疾病谱的一部分，还包括淋巴瘤样丘疹病。它常发生于老年患者，中位发病年龄为 60 岁，但也可发生于任何年龄。它是一种由大细胞组成的 CD30+T 细胞肿瘤，具有间变性、多形性或免疫母细胞形态，仅发生于皮肤且定位于此。pcALCL 的临床病程主要为惰性。大多数老年淋巴瘤患者往往生活方式久坐不动，这对他们的生活质量（QoL）和生存产生负面影响。多项研究表明，运动对 QoL 有积极影响，因为它可降低峰值耗氧量、提高身体能力、增加自尊心、减轻累积压力并促进放松。因此，特别是在惰性淋巴瘤中，有必要系统地进行体育活动方案。对于单发皮损的 pcALCL，完整的手术切除和局部放疗是一线金标准。
