Cagetti M G, Brambilla E, Fadini L, Strohmenger L
Department of Pediatric Dentistry S. Paolo Department of Medicine, Surgery and Dentistry University of Milan, Milan, Italy.
Eur J Paediatr Dent. 2002 Mar;3(1):27-32.
The aim of the present study was to compare the effect of a chewing gum containing 0.50 mg fluoride with two tablets containing 0.25 mg fluoride as NaF, on the salivary and urinary fluoride concentration in children. MATERIALS AND METHODS: Whole saliva and urine were sampled from twenty 5-9 years-old children to assess the baseline fluoride concentrations. The day after, the subjects were asked to chew the fluoridated chewing gum for 15 minutes and saliva samples were collected 5, 10, 30, 60, 120, 240 minutes after ceasing the use of the chewing gum. Urine samples were collected 1, 2, 4 and 24 hours after the use of the gum. After a washout period of one week, the subjects were recalled and were asked to completely dissolve two 0.25 mg fluoride tablets in their mouth. Saliva and urine samples were collected in the same way. Fluoride concentration in saliva and urine was determined using a fluoride specific electrode. RESULTS: No significant differences were found in the concentrations of fluoride in saliva or urine using fluoridated chewing gum and tablets. CONCLUSION: The NaF tablets and chewing gum studied had approximately the same clearance pattern in saliva and urine. These data show that the chewing gum examined could be a valid alternative to the use of NaF tablets in caries prevention.
本研究旨在比较含0.50毫克氟化物的口香糖与两片含0.25毫克氟化钠的片剂对儿童唾液和尿液中氟化物浓度的影响。材料与方法：从20名5至9岁儿童中采集全唾液和尿液样本，以评估基线氟化物浓度。次日，让受试者咀嚼含氟口香糖15分钟，并在停止咀嚼口香糖后5、10、30、60、120、240分钟收集唾液样本。在使用口香糖后1、2、4和24小时收集尿液样本。经过一周的洗脱期后，召回受试者，让他们将两片0.25毫克的氟化物片剂在口中完全溶解。以相同方式收集唾液和尿液样本。使用氟化物特异性电极测定唾液和尿液中的氟化物浓度。结果：使用含氟口香糖和片剂时，唾液或尿液中氟化物浓度未发现显著差异。结论：所研究的氟化钠片剂和口香糖在唾液和尿液中的清除模式大致相同。这些数据表明，所检测的口香糖在预防龋齿方面可能是使用氟化钠片剂的有效替代品。
