The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.
作者信息
Feron Olivier
机构信息
Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Brussels, Belgium.
出版信息
Ann Transl Med. 2019 Dec;7(Suppl 8):S277. doi: 10.21037/atm.2019.11.140.
Abstract
摘要
相似文献
1
The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.支持组蛋白乙酰化并影响癌症进展的乙酰辅酶A的多种代谢来源。
Ann Transl Med. 2019 Dec;7(Suppl 8):S277. doi: 10.21037/atm.2019.11.140.
2
Integrated Analysis of Acetyl-CoA and Histone Modification via Mass Spectrometry to Investigate Metabolically Driven Acetylation.通过质谱法对乙酰辅酶A和组蛋白修饰进行综合分析以研究代谢驱动的乙酰化作用。
Methods Mol Biol. 2019;1928:125-147. doi: 10.1007/978-1-4939-9027-6_9.
3
Crosstalk between cellular metabolism and histone acetylation.细胞代谢与组蛋白乙酰化之间的相互作用。
Methods Enzymol. 2019;626:1-21. doi: 10.1016/bs.mie.2019.07.013. Epub 2019 Aug 12.
4
Cytosolic acetyl-CoA promotes histone acetylation predominantly at H3K27 in Arabidopsis.细胞质乙酰辅酶 A 主要促进拟南芥组蛋白 H3K27 的乙酰化。
Nat Plants. 2017 Oct;3(10):814-824. doi: 10.1038/s41477-017-0023-7. Epub 2017 Sep 25.
5
Acetyl-CoA and the regulation of metabolism: mechanisms and consequences.乙酰辅酶A与代谢调节：机制与后果
Curr Opin Cell Biol. 2015 Apr;33:125-31. doi: 10.1016/j.ceb.2015.02.003. Epub 2015 Feb 20.
6
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory.乙酰辅酶A合成酶调节组蛋白乙酰化和海马体记忆。
Nature. 2017 Jun 15;546(7658):381-386. doi: 10.1038/nature22405. Epub 2017 May 31.
7
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.细胞核胞质乙酰辅酶A合成酶是组蛋白乙酰化和整体转录所必需的。
Mol Cell. 2006 Jul 21;23(2):207-17. doi: 10.1016/j.molcel.2006.05.040.
8
The Various Metabolic Sources of Histone Acetylation.组蛋白乙酰化的各种代谢来源。
Trends Endocrinol Metab. 2017 Feb;28(2):85-87. doi: 10.1016/j.tem.2016.11.001. Epub 2016 Nov 16.
9
Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis.醋酸盐，急性酒精性肝炎炎症反应的关键调节物。
Hepatology. 2010 Jun;51(6):1988-97. doi: 10.1002/hep.23572.
10
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.糖酵解介导的乙酰辅酶 A 变化和组蛋白乙酰化控制胚胎干细胞的早期分化。
Cell Metab. 2015 Mar 3;21(3):392-402. doi: 10.1016/j.cmet.2015.02.002.
引用本文的文献
1
Epigenetic regulation of transcription factors involved in NLRP3 inflammasome and NF-kB signaling pathways.参与NLRP3炎性小体和NF-κB信号通路的转录因子的表观遗传调控。
Front Immunol. 2025 Feb 19;16:1529756. doi: 10.3389/fimmu.2025.1529756. eCollection 2025.
2
Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells.选择性且可穿透血脑屏障的ACSS2抑制剂靶向乳腺癌脑转移细胞。
Front Pharmacol. 2024 May 16;15:1394685. doi: 10.3389/fphar.2024.1394685. eCollection 2024.
3
Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease.外周动脉疾病中的血管生成的表观遗传调控。
Methodist Debakey Cardiovasc J. 2023 Nov 16;19(5):47-57. doi: 10.14797/mdcvj.1294. eCollection 2023.
4
Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism.通过核 LDH 代谢，乳酸作为组蛋白乙酰化的主要表观遗传碳源。
Exp Mol Med. 2023 Oct;55(10):2238-2247. doi: 10.1038/s12276-023-01095-w. Epub 2023 Oct 2.
5
The Lipid Metabolism as Target and Modulator of BOLD-100 Anticancer Activity: Crosstalk with Histone Acetylation.脂代谢作为 BOLD-100 抗癌活性的靶点和调节剂：与组蛋白乙酰化的串扰。
Adv Sci (Weinh). 2023 Nov;10(32):e2301939. doi: 10.1002/advs.202301939. Epub 2023 Sep 26.
6
TMEM120A-mediated regulation of chemotherapy sensitivity in colorectal cancer cells.TMEM120A 介导调控结直肠癌细胞对化疗的敏感性。
Cancer Chemother Pharmacol. 2024 Jan;93(1):11-22. doi: 10.1007/s00280-023-04594-9. Epub 2023 Sep 20.
7
Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing.代谢与表观遗传的相互作用为慢性病和衰老提供了有针对性的营养干预措施。
Front Oncol. 2023 Jun 19;13:1169168. doi: 10.3389/fonc.2023.1169168. eCollection 2023.
8
Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress.细胞器间通讯在代谢应激下支持乙酰辅酶 A 动态平衡和脂肪生成。
Sci Adv. 2023 May 3;9(18):eadf0138. doi: 10.1126/sciadv.adf0138.
9
Aggrelyte-2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia.Aggrelyte-2 通过赖氨酸乙酰化和二硫键还原提高蛋白质溶解度并降低晶状体硬度：治疗远视的潜在应用。
Aging Cell. 2023 Apr;22(4):e13797. doi: 10.1111/acel.13797. Epub 2023 Feb 23.
10
Extracellular Citrate Treatment Induces HIF1α Degradation and Inhibits the Growth of Low-Glycolytic Hepatocellular Carcinoma under Hypoxia.细胞外柠檬酸盐处理可诱导缺氧条件下低糖酵解型肝癌中HIF1α的降解并抑制其生长。
Cancers (Basel). 2022 Jul 10;14(14):3355. doi: 10.3390/cancers14143355.
本文引用的文献
1
Dealing with saturated and unsaturated fatty acid metabolism for anticancer therapy.应对饱和脂肪酸和不饱和脂肪酸代谢以用于抗癌治疗。
Curr Opin Clin Nutr Metab Care. 2019 Nov;22(6):427-433. doi: 10.1097/MCO.0000000000000601.
2
Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers.核糖原分解调节人非小细胞肺癌中的组蛋白乙酰化。
Cell Metab. 2019 Nov 5;30(5):903-916.e7. doi: 10.1016/j.cmet.2019.08.014. Epub 2019 Sep 12.
3
Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non-Small Cell Lung Cancer.帕博利珠单抗联合伏立诺他治疗晚期/转移性非小细胞肺癌的 I/ Ib 期研究。
Clin Cancer Res. 2019 Nov 15;25(22):6623-6632. doi: 10.1158/1078-0432.CCR-19-1305. Epub 2019 Aug 13.
4
Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription.乙酰化与伙伴：组蛋白酰化修饰的不断扩展调控染色质和转录。
Essays Biochem. 2019 Apr 23;63(1):97-107. doi: 10.1042/EBC20180061.
5
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.乙酰辅酶 A 代谢支持多步骤胰腺肿瘤发生。
Cancer Discov. 2019 Mar;9(3):416-435. doi: 10.1158/2159-8290.CD-18-0567. Epub 2019 Jan 9.
6
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.成纤维细胞动员肿瘤细胞糖原促进增殖和转移。
Cell Metab. 2019 Jan 8;29(1):141-155.e9. doi: 10.1016/j.cmet.2018.08.007. Epub 2018 Aug 30.
7
Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity.星形胶质细胞糖原衍生的乳酸为大脑在剧烈运动中供能，以维持耐力。
Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6358-6363. doi: 10.1073/pnas.1702739114. Epub 2017 May 17.
8
Emerging roles of lipid metabolism in cancer progression.脂质代谢在癌症进展中的新作用。
Curr Opin Clin Nutr Metab Care. 2017 Jul;20(4):254-260. doi: 10.1097/MCO.0000000000000381.
9
Cancer cell metabolism and mitochondria: Nutrient plasticity for TCA cycle fueling.癌细胞代谢与线粒体：三羧酸循环燃料的营养可塑性。
Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):7-15. doi: 10.1016/j.bbcan.2017.01.002. Epub 2017 Jan 18.
10
Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.脂质重编程代谢以成为组蛋白乙酰化的主要碳源。
Cell Rep. 2016 Nov 1;17(6):1463-1472. doi: 10.1016/j.celrep.2016.10.012.
Zotero 插件