利用新型快速响应荧光探针成像动脉粥样硬化中的内源性 HClO。
Imaging endogenous HClO in atherosclerosis using a novel fast-response fluorescence probe.
机构信息
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
出版信息
Chem Commun (Camb). 2020 Feb 28;56(17):2598-2601. doi: 10.1039/c9cc07256j. Epub 2020 Feb 4.
PMID:32016205
Abstract
A novel pyrene-based naked-eye colorimetric and fluorescent turn-on probe (S-ClO) was developed. Besides, imaging in living RAW264.7 cells, an arterial vessel inflammation nude mouse model and human serum using S-ClO indicates that S-ClO could serve as a potential tool for early diagnosing and monitoring inflammatory diseases.
摘要
一种新型的基于芘的裸眼比色和荧光开启探针（S-ClO）被开发出来。此外，使用 S-ClO 对活体 RAW264.7 细胞、动脉血管炎症裸鼠模型和人血清进行成像表明，S-ClO 可以作为一种潜在的工具，用于早期诊断和监测炎症性疾病。
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