Tertsunen Hanna-Mari, Hantunen Sari, Tuomainen Tomi-Pekka, Virtanen Jyrki K
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Eur J Nutr. 2020 Dec;59(8):3545-3553. doi: 10.1007/s00394-020-02188-2. Epub 2020 Feb 3.
To investigate the association between healthy Nordic diet and risk of disease death in middle-aged and older men from eastern Finland.
A total of 1547 men aged 42-60 years and free of cardiovascular disease (CVD), cancer and type 2 diabetes at baseline in 1984-1989 were included. Diet was assessed with 4-day food records at baseline and the healthy Nordic diet score was calculated based on the Baltic Sea Diet Score. The incidence of death was assessed by a computer linkage to the national cause of death register. Cox proportional hazards regression analyses were used to estimate the associations between the healthy Nordic diet score and mortality.
During the mean follow-up of 23.6 years (SD 7.0), 576 men died due to disease: 250 due to CVD, 194 due to cancer and 132 due to other diseases. The multivariable-adjusted hazard ratios (95% confidence interval) in the lowest vs. the highest quartile of the healthy Nordic diet score were 1.27 (1.01-1.59) for any disease death (P-trend across quartiles < 0.001), 1.39 (0.99-1.97, P-trend = 0.049) for CVD death, 1.26 (0.84-1.89, P-trend = 0.316) for cancer death and 1.04 (0.65-1.68, P-trend = 0.563) for other disease deaths.
In this prospective population-based cohort study among middle-aged and older men, low adherence to a healthy Nordic diet was associated with a higher risk of any disease death, possibly largely attributable to higher CVD mortality.
研究健康的北欧饮食与芬兰东部中老年男性疾病死亡风险之间的关联。
纳入了1984年至1989年基线时年龄在42 - 60岁且无心血管疾病（CVD）、癌症和2型糖尿病的1547名男性。在基线时通过4天的食物记录评估饮食，并基于波罗的海饮食评分计算健康的北欧饮食评分。通过与国家死亡原因登记处的计算机链接评估死亡发生率。采用Cox比例风险回归分析来估计健康的北欧饮食评分与死亡率之间的关联。
在平均23.6年（标准差7.0）的随访期间，576名男性因病死亡：250人死于CVD，194人死于癌症，132人死于其他疾病。健康的北欧饮食评分最低四分位数与最高四分位数相比，多变量调整后的风险比（95%置信区间）为：任何疾病死亡为1.27（1.01 - 1.59）（四分位数间P趋势<0.001），CVD死亡为1.39（0.99 - 1.97，P趋势 = 0.049），癌症死亡为1.26（0.84 - 1.89，P趋势 = 0.316），其他疾病死亡为1.04（0.65 - 1.68，P趋势 = 0.563）。
在这项针对中老年男性的基于人群的前瞻性队列研究中，对健康的北欧饮食依从性低与任何疾病死亡风险较高相关，这可能很大程度上归因于较高的CVD死亡率。
