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遵循健康的北欧饮食与男性 2 型糖尿病风险之间的关系:库奥皮奥缺血性心脏病风险因素研究。

Adherence to a healthy Nordic diet and risk of type 2 diabetes among men: the Kuopio Ischaemic Heart Disease Risk Factor Study.

机构信息

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

出版信息

Eur J Nutr. 2021 Oct;60(7):3927-3934. doi: 10.1007/s00394-021-02569-1. Epub 2021 Apr 27.

Abstract

PURPOSE

To investigate the association between healthy Nordic diet and risk of type 2 diabetes (T2D) in middle-aged and older men from eastern Finland.

METHODS

A total of 2332 men aged 42-60 years and free of T2D at baseline in 1984-1989 were included. Diet was assessed with 4-day food records at baseline and the healthy Nordic diet score was calculated based on a modified Baltic Sea Diet Score. T2D diagnosis was based on self-administered questionnaires, fasting and 2-h oral glucose tolerance test blood glucose measurements, or by record linkage to national health registries. Cox proportional hazards regression and analysis of covariance were used for analyses.

RESULTS

During the mean follow-up of 19.3 years, 432 men (18.5%) were diagnosed with T2D. The multivariable-adjusted hazard ratio for T2D in the lowest vs. the highest quartile of the healthy Nordic diet score was 1.35 (95% CI 1.03-1.76) (P trend across quartiles 0.028). Lower adherence to healthy Nordic diet was also associated with higher plasma glucose and insulin concentrations.

CONCLUSIONS

In this prospective population-based cohort study among middle-aged and older men from eastern Finland, lower adherence to healthy Nordic diet was associated with higher risk of T2D and higher plasma glucose and serum insulin concentrations.

摘要

目的

研究芬兰东部中年和老年男性中健康的北欧饮食与 2 型糖尿病(T2D)风险之间的关联。

方法

共有 2332 名年龄在 42-60 岁且在 1984-1989 年基线时无 T2D 的男性纳入研究。饮食采用 4 天的食物记录在基线时进行评估,并根据改良的波罗的海饮食评分计算健康的北欧饮食评分。T2D 的诊断基于自我报告的问卷、空腹和 2 小时口服葡萄糖耐量试验血糖测量,或通过与国家健康登记处的记录链接进行诊断。使用 Cox 比例风险回归和协方差分析进行分析。

结果

在平均 19.3 年的随访期间,有 432 名男性(18.5%)被诊断患有 T2D。最低与最高四分位区间健康北欧饮食评分的 T2D 多变量调整后的风险比为 1.35(95%CI 1.03-1.76)(P 趋势=0.028)。健康北欧饮食的依从性较低与较高的血浆葡萄糖和胰岛素浓度也有关。

结论

在芬兰东部中年和老年男性的这项前瞻性基于人群的队列研究中,较低的健康北欧饮食依从性与较高的 T2D 风险以及较高的血浆葡萄糖和血清胰岛素浓度有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54e/8437904/a55c0d6c6717/394_2021_2569_Fig1_HTML.jpg

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