硫胺素、核黄素、维生素B-6和维生素C：联合限制摄入量对人体功能表现的影响。

Thiamin, riboflavin, and vitamins B-6 and C: impact of combined restricted intake on functional performance in man.

作者信息

van der Beek E J, van Dokkum W, Schrijver J, Wedel M, Gaillard A W, Wesstra A, van de Weerd H, Hermus R J

机构信息

Department of Human Nutrition, TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.

出版信息

Am J Clin Nutr. 1988 Dec;48(6):1451-62. doi: 10.1093/ajcn/48.6.1451.

DOI:10.1093/ajcn/48.6.1451

PMID:3202095

Abstract

A double-blind study of combined restriction of thiamin, riboflavin, and vitamins B-6 and C was carried out with 23 healthy males. During 8 wk of low vitamin intake, 12 deficient subjects consumed daily a diet of normal food products, providing maximally 32.5% of the Dutch Recommended Dietary Allowances (RDA) for thiamin, riboflavin, vitamins B-6 and C. Other vitamins were supplemented at twice the RDA. Eleven control subjects consumed the same diet but with a supplementation of twice the RDA of all vitamins. In deficient subjects blood vitamin levels, urinary vitamin excretion, and erythrocytic enzyme activities decreased; in vitro enzyme stimulation increased. Vitamin depletion had no ill effects on health, physical activity, and mental performance. A significant decrease was observed in aerobic power (VO2max) and onset of blood lactate accumulation (p less than 0.001) of 9.8 and 19.6%, respectively. A combined restricted intake of thiamin, riboflavin, and vitamins B-6 and C causes a decrease in physical performance within a few weeks.

摘要

对23名健康男性进行了一项关于硫胺素、核黄素、维生素B - 6和维生素C联合限制摄入的双盲研究。在8周的低维生素摄入期间，12名缺乏维生素的受试者每天食用正常食品组成的饮食，所提供的硫胺素、核黄素、维生素B - 6和维生素C最多为荷兰推荐膳食摄入量（RDA）的32.5%。其他维生素则按RDA的两倍进行补充。11名对照受试者食用相同的饮食，但所有维生素的补充量为RDA的两倍。在缺乏维生素的受试者中，血液维生素水平、尿维生素排泄量和红细胞酶活性均下降；体外酶刺激增加。维生素缺乏对健康、体力活动和心理表现没有不良影响。观察到有氧能力（最大摄氧量）和血乳酸积累起始点分别显著下降了9.8%和19.6%（p<0.001）。硫胺素、核黄素、维生素B - 6和维生素C的联合限制摄入会在几周内导致身体机能下降。