[2019新型冠状病毒的潜在抗病毒治疗方法]
[Potential antiviral therapeutics for 2019 Novel Coronavirus].
作者信息
Li H, Wang Y M, Xu J Y, Cao B
机构信息
Center of Respiratory Medicine, China-Japan Friendship Hospital; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, Beijing 100020, China.
Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Feb 5;43(0):E002. doi: 10.3760/cma.j.issn.1001-0939.2020.0002.
The recent outbreak of respiratory illness in Wuhan, China is caused by a novel coronavirus, named 2019-nCoV, which is genetically close to a bat-derived coronavirus. 2019-nCoV is categorized as beta genus coronavirus, same as the two other strains - severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Antiviral drugs commonly used in clinical practice, including neuraminidase inhibitors (oseltamivir, paramivir, zanamivir, etc.), ganciclovir, acyclovir and ribavirin, are invalid for 2019-nCoV and not recommended. Drugs are possibly effective for 2019-nCoV include: remdesivir, lopinavir / ritonavir, lopinavir / ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials.
中国武汉近期爆发的呼吸道疾病由一种新型冠状病毒引起，该病毒名为2019-nCoV，在基因上与一种源自蝙蝠的冠状病毒相近。2019-nCoV被归类为β属冠状病毒，与另外两种毒株——严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）相同。临床实践中常用的抗病毒药物，包括神经氨酸酶抑制剂（奥司他韦、帕拉米韦、扎那米韦等）、更昔洛韦、阿昔洛韦和利巴韦林，对2019-nCoV无效，不建议使用。可能对2019-nCoV有效的药物包括：瑞德西韦、洛匹那韦/利托那韦、洛匹那韦/利托那韦联合干扰素-β、康复期血浆和单克隆抗体。但这些药物对2019-nCoV肺炎患者的疗效和安全性需要通过进一步的临床试验来评估。
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