Fujimoto Ayumi, Suzuki Ritsuro
Department of Oncology and Hematology, Shimane University Hospital, Izumo 693-8501, Japan.
Cancers (Basel). 2020 Feb 1;12(2):328. doi: 10.3390/cancers12020328.
Epstein-Barr virus (EBV) is a ubiquitous virus belonging to the human -herpes virus subfamily. After primary infection, EBV maintains a life-long latent infection. A major concern is that EBV can cause a diverse range of neoplasms and autoimmune diseases. In addition, patients undergoing hematopoietic stem cell transplantation or solid organ transplantation can experience post-transplant lymphoproliferative disorders (PTLDs) due to dysfunction or suppression of host's immune system, or uncontrolled proliferation of EBV-infected cells. In recent years, the number of EBV-associated PTLD cases has increased. This review focuses on the current understandings of EBV-associated PTLD pathogenesis, as well as the risk factors and clinical outcomes for patients after allogeneic stem cell transplantation.
爱泼斯坦-巴尔病毒（EBV）是一种普遍存在的病毒，属于人类疱疹病毒亚科。初次感染后，EBV会维持终身潜伏感染。一个主要问题是，EBV可引发多种肿瘤和自身免疫性疾病。此外，接受造血干细胞移植或实体器官移植的患者，由于宿主免疫系统功能障碍或受到抑制，或者EBV感染细胞不受控制地增殖，可能会发生移植后淋巴细胞增殖性疾病（PTLD）。近年来，EBV相关PTLD病例的数量有所增加。本综述聚焦于对EBV相关PTLD发病机制的当前认识，以及异基因干细胞移植后患者的危险因素和临床结局。
