Department of Biology, Faculty of Sciences, Autónoma University of Madrid (UAM), Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28049 Madrid, Spain.
Medical Affairs Department, Cantabria Labs, 28043 Madrid, Spain.
Int J Mol Sci. 2020 Feb 2;21(3):988. doi: 10.3390/ijms21030988.
Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices. This, together with recent observations reporting that blue light-also known as high-energy visible light-can exert cytotoxic effects associated with oxidative stress and promote hyperpigmentation, has sparked interest in blue light and its potential harmful effects on skin. The photoprotective properties of new extracts of different botanicals with antioxidant activity are therefore being studied. (Edafence, EDA), a natural aqueous extract, has shown keratinocyte and fibroblast cell protection effects against ultraviolet radiation and dioxin toxicity. In this regard, we studied the protective capacity of EDA against the deleterious effects of artificial blue light irradiation in human dermal fibroblasts (HDF) and melanocytes. We analyzed the impact of EDA on viability, cell morphology, oxidative stress, melanogenic signaling pathway activation and hyperpigmentation in HDF and melanocytes subjected to artificial blue light irradiation. Our results show that EDA protects against cell damage caused by artificial blue light, decreasing oxidative stress, melanogenic signaling pathway activation and hyperpigmentation caused by blue light irradiation. All these findings suggest that EDA might help prevent skin damage produced by artificial blue light exposure from screen of electronic devices.
由于电子设备的广泛使用，皮肤越来越多地暴露在人造蓝光下。此外，最近有观察报告称，蓝光——也被称为高能可见光——会产生与氧化应激相关的细胞毒性作用，并促进色素沉着过度，这引起了人们对蓝光及其对皮肤潜在有害影响的兴趣。因此，正在研究具有抗氧化活性的不同植物提取物的光保护特性。Edafence（EDA）是一种天然的水性提取物，已显示出对角质形成细胞和成纤维细胞紫外线辐射和二恶英毒性的保护作用。在这方面，我们研究了 EDA 对人真皮成纤维细胞（HDF）和黑素细胞中人工蓝光照射的有害影响的保护能力。我们分析了 EDA 对人工蓝光照射下 HDF 和黑素细胞活力、细胞形态、氧化应激、黑素生成信号通路激活和色素沉着过度的影响。我们的结果表明，EDA 可防止人工蓝光照射引起的细胞损伤，减少由蓝光照射引起的氧化应激、黑素生成信号通路激活和色素沉着过度。所有这些发现表明，EDA 可能有助于防止电子设备屏幕发出的人造蓝光暴露对皮肤造成的损伤。
