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从[植物名称（未给出完整）]制备的富含金丝桃苷的组分通过MAPK信号通路对紫外线B诱导的人成纤维细胞皮肤老化的光保护作用。

Photoprotective Effects of a Hyperoside-Enriched Fraction Prepared from Thunb. on Ultraviolet B-Induced Skin Aging in Human Fibroblasts through the MAPK Signaling Pathway.

作者信息

Mapoung Sariya, Umsumarng Sonthaya, Semmarath Warathit, Arjsri Punnida, Srisawad Kamonwan, Thippraphan Pilaiporn, Yodkeeree Supachai, Dejkriengkraikul Pornngarm

机构信息

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Center for Research and Development of Natural Products for Health, Chiang Mai University, Chiang Mai 50200, Thailand.

出版信息

Plants (Basel). 2021 Nov 29;10(12):2628. doi: 10.3390/plants10122628.

DOI:10.3390/plants10122628
PMID:34961096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8708340/
Abstract

Ultraviolet-B (UVB) irradiation causes skin damage via deleterious effects including oxidative stress, inflammation, and collagen degradation. The photoprotective effects of a hyperoside-enriched fraction obtained from Thunb. () on the attenuation of UVB-induced skin aging in human fibroblasts were investigated. The solvent-partition technique was used to establish the hyperoside-enriched fraction of (HcEA). The active compounds identified in the extracts were hyperoside, quercitrin, chlorogenic acid, and rutin. With regard to the photoprotective effects of on UVB-irradiated dermal fibroblasts, HcEA and hyperoside inhibited intracellular ROS production and inflammatory cytokine secretions (IL-6 and IL-8), while increasing collagen type I synthesis along with downregulating MMP-1 gene and protein expressions. Mechanistically, the hyperoside-enriched fraction obtained from inhibited UVB-irradiated skin aging through regulation of the MAPK signaling pathway by attenuating the activation of JNK/ERK/c-Jun in human dermal fibroblasts. The hyperoside-enriched fraction of exerted potent anti-skin aging properties against UVB exposure. The findings of this study can be applied in the cosmetics industry, as extract can potentially be used in pharmaceutical or cosmetic formulations as a photoprotective or anti-skin aging agent.

摘要

紫外线B（UVB）照射通过氧化应激、炎症和胶原蛋白降解等有害作用导致皮肤损伤。研究了从[植物名称未完整给出]中获得的富含金丝桃苷的提取物对减轻人成纤维细胞中UVB诱导的皮肤衰老的光保护作用。采用溶剂分配技术制备了[植物名称未完整给出]富含金丝桃苷的提取物（HcEA）。在该提取物中鉴定出的活性化合物有金丝桃苷、槲皮苷、绿原酸和芦丁。关于[植物名称未完整给出]对UVB照射的真皮成纤维细胞的光保护作用，HcEA和金丝桃苷抑制细胞内活性氧的产生和炎性细胞因子（IL-6和IL-8）的分泌，同时增加I型胶原蛋白的合成，并下调MMP-1基因和蛋白的表达。从机制上讲，从[植物名称未完整给出]中获得的富含金丝桃苷的提取物通过调节丝裂原活化蛋白激酶（MAPK）信号通路，减弱人真皮成纤维细胞中JNK/ERK/c-Jun的激活，从而抑制UVB照射引起的皮肤衰老。[植物名称未完整给出]富含金丝桃苷的提取物对UVB照射具有强大的抗皮肤衰老特性。本研究结果可应用于化妆品行业，因为[植物名称未完整给出]提取物有可能作为光保护剂或抗皮肤衰老剂用于制药或化妆品配方中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/41a9cec4c2ed/plants-10-02628-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/e80326d546e2/plants-10-02628-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/b87f69e6a619/plants-10-02628-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/1de9634be340/plants-10-02628-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/d846a9cc0cf9/plants-10-02628-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/0da962cb3839/plants-10-02628-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/949973d32b33/plants-10-02628-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/41a9cec4c2ed/plants-10-02628-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/e80326d546e2/plants-10-02628-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/b87f69e6a619/plants-10-02628-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/1de9634be340/plants-10-02628-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/d846a9cc0cf9/plants-10-02628-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/0da962cb3839/plants-10-02628-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/949973d32b33/plants-10-02628-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/731d/8708340/41a9cec4c2ed/plants-10-02628-g007.jpg

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