药物发现：今日与明日。
Drug Discovery: Today and Tomorrow.
作者信息
Flower Darren R
机构信息
Independent Interdisciplinary Consultant, Oxford, United Kingdom.
出版信息
Bioinformation. 2020 Jan 1;16(1):1-3. doi: 10.6026/97320630016001. eCollection 2020.
Abstract
Drug discovery continues to underperform relative to unmet medical need. Driven by profit not societal need, the search for new drugs is neither properly funded nor sufficiently systematic. Many innovative approaches are significantly underused yet extant methodology is replete with problems. In and of itself, technical innovation is unlikely to fulfill the potential of drug discovery if the supporting infrastructure remains unchanged.
摘要
相对于未满足的医疗需求，药物研发的表现持续不佳。受利润而非社会需求驱动，新药研发既没有得到充足的资金支持，也缺乏足够的系统性。许多创新方法未得到充分利用，而现有方法却问题重重。如果支持性基础设施保持不变，技术创新本身不太可能实现药物研发的潜力。
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