Kotera Atsushi
Department of Anesthesiology, Kumamoto Central Hospital, 955 Muro, Ozu-machi Kikuchi-gun, Kumamoto, 869-1235, Japan.
JA Clin Rep. 2019 Sep 25;5(1):62. doi: 10.1186/s40981-019-0282-6.
The Geriatric Nutritional Risk Index (GNRI) based on serum albumin level and body weight and the Controlling Nutritional Status Score (CONUT) based on serum albumin level, total cholesterol level, and total lymphocyte count were created to evaluate objectively a patient's nutritional status in 2005. Here we validated the usefulness of the GNRI and the CONUT as a prognostic factor of the 180-day mortality in patients who underwent hip fracture surgeries. We retrospectively collected data from patients with hip surgeries performed from January 2012 to December 2018. The variables required for the GNRI and the CONUT and the factors presumably associated with postoperative mortality including the patients' characteristics were collected from the medical charts. Intergroup differences were assessed with the χ test with Yates' correlation for continuity in category variables. The Mann-Whitney U test was used to test for differences in continuous variables. We validated the power of the GNRI and the CONUT values to distinguish patients who died ≤ 180 days post-surgery from those who did not, by calculating the area under the receiver operating characteristic curve (AUC). The correlation between these two models was analyzed by Spearman's rank correlation (ρ).
We retrospectively examined the cases of 607 patients aged 87 ± 6 (range 70-102) years old. The 180-day mortality rate was 5.4% (n = 33 non-survivors). The GNRI value in the non-survivors was 83 ± 9 (range 66-111), which was significantly lower than that in the survivors at 92 ± 9 (range 64-120). The CONUT value in the non-survivors was 6 ± 3 (range 1-11), which was significantly higher than that in the survivors at 4 ± 2 (range 0-11). The AUC value to predict the 180-day mortality was 0.74 for the GNRI and 0.72 for the CONUT. The ρ value between these two models was 0.61 in the total of 607 patients and was 0.78 in the 33 non-survivors.
Our results suggest that the GNRI and the CONUT are a simple and useful tool to predict the 180-day mortality in patients who have undergone a hip surgery.
基于血清白蛋白水平和体重的老年营养风险指数(GNRI)以及基于血清白蛋白水平、总胆固醇水平和总淋巴细胞计数的控制营养状况评分(CONUT)于2005年被创建,用于客观评估患者的营养状况。在此,我们验证了GNRI和CONUT作为髋部骨折手术患者180天死亡率的预后因素的有效性。我们回顾性收集了2012年1月至2018年12月接受髋部手术患者的数据。从病历中收集GNRI和CONUT所需的变量以及可能与术后死亡率相关的因素,包括患者的特征。分类变量组间差异采用连续性校正的χ检验进行评估。连续变量差异采用曼-惠特尼U检验。通过计算受试者工作特征曲线(AUC)下的面积,我们验证了GNRI和CONUT值区分术后≤180天死亡患者和未死亡患者的能力。通过Spearman等级相关性(ρ)分析这两种模型之间的相关性。
我们回顾性研究了607例年龄为87±6(范围70 - 102)岁患者的病例。180天死亡率为5.4%(n = 33例非幸存者)。非幸存者的GNRI值为83±9(范围66 - 111),显著低于幸存者的92±9(范围64 - 120)。非幸存者的CONUT值为6±3(范围1 - 11),显著高于幸存者的4±2(范围0 - 11)。预测180天死亡率的AUC值,GNRI为0.74,CONUT为0.72。在607例患者总数中,这两种模型之间的ρ值为0.61,在33例非幸存者中为0.78。
我们的结果表明,GNRI和CONUT是预测髋部手术患者180天死亡率的简单且有用的工具。