Department of Orthodontics , Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology , 22 Zhongguancun South Avenue , Haidian District, Beijing 100081 , P. R. China.
CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry , Chinese Academy of Sciences , Beijing 100190 , P. R. China.
ACS Appl Mater Interfaces. 2020 Feb 26;12(8):9718-9725. doi: 10.1021/acsami.9b19873. Epub 2020 Feb 17.
Bacterial infection is the main cause of implantation failure worldwide, and the importance of antibiotics on medical devices has been undermined because of antibiotic resistance. Antimicrobial hydrogels have emerged as a promising approach to combat infections associated with medical devices and wound healing. However, hydrogel coatings that simultaneously possess both antifouling and antimicrobial attributes are scarce. Herein, we report an antimicrobial hydrogel that incorporates adhesion-inhibiting polyethylene glycol (PEG) and colony-suppressing chitosan (CS) as a dressing to combat bacterial infections. These two polymers have important environmentally benign characteristics including low toxicity, low volatility, and biocompatibility. Although hydrogels containing PEG and CS have been reported for applications in the fields of wound dressing, tissue repair, water purification, drug delivery, and scaffolds for bone regeneration, there still has been no report on the application of CS/PEG hydrogel coatings in dental applications. Herein, this biointerface shows superior activity in early-stage adhesion inhibition (98.8%, 5 h) and displays remarkably long-lasting colony-suppression activity (93.3%, 7 d). Thus, this novel nanomaterial, which has potential as a dual-functional platform with integrated antifouling and antimicrobial functions with excellent biocompatibility, might be used as a safe and effective antimicrobial coating in biomedical device applications.
细菌感染是全球范围内导致种植体失败的主要原因，而由于抗生素耐药性的出现，抗生素在医疗器械中的重要性被削弱。抗菌水凝胶作为一种有前途的方法，已经出现来对抗与医疗器械和伤口愈合相关的感染。然而，同时具有抗污和抗菌特性的水凝胶涂层仍然很少。在此，我们报告了一种抗菌水凝胶，它将具有抑制黏附功能的聚乙二醇（PEG）和具有抑制菌落功能的壳聚糖（CS）结合在一起，作为一种敷料来对抗细菌感染。这两种聚合物具有重要的环境友好特性，包括低毒性、低挥发性和生物相容性。尽管含有 PEG 和 CS 的水凝胶已经被报道用于伤口敷料、组织修复、水净化、药物输送以及骨再生支架等领域，但在牙科应用中，CS/PEG 水凝胶涂层的应用仍未见报道。在此，这种生物界面在早期黏附抑制方面表现出优异的活性（98.8%，5 小时），并且表现出显著的长期抑制菌落活性（93.3%，7 天）。因此，这种新型纳米材料具有作为具有集成抗污和抗菌功能的双功能平台的潜力，并且具有出色的生物相容性，可能被用作生物医学设备应用中的安全有效的抗菌涂层。
