Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter, School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China.
Institute of Orthopaedics and Musculoskeletal Science, Division of Surgery and Interventional Science, University College London, Royal National Orthopaedic Hospital, London HA4 4LP, UK.
Molecules. 2023 May 7;28(9):3946. doi: 10.3390/molecules28093946.
Oral health is crucial to daily life, yet many people worldwide suffer from oral diseases. With the development of oral tissue engineering, there is a growing demand for dental biomaterials. Addressing oral diseases often requires a two-fold approach: fighting bacterial infections and promoting tissue growth. Hydrogels are promising tissue engineering biomaterials that show great potential for oral tissue regeneration and drug delivery. In this review, we present a classification of hydrogels commonly used in dental research, including natural and synthetic hydrogels. Furthermore, recent applications of these hydrogels in endodontic restorations, periodontal tissues, mandibular and oral soft tissue restorations, and related clinical studies are also discussed, including various antimicrobial and tissue growth promotion strategies used in the dental applications of hydrogels. While hydrogels have been increasingly studied in oral tissue engineering, there are still some challenges that need to be addressed for satisfactory clinical outcomes. This paper summarizes the current issues in the abovementioned application areas and discusses possible future developments.
口腔健康对日常生活至关重要，但世界上仍有许多人患有口腔疾病。随着口腔组织工程学的发展，对牙科生物材料的需求日益增长。治疗口腔疾病通常需要双管齐下：对抗细菌感染和促进组织生长。水凝胶是一种很有前途的组织工程生物材料，在口腔组织再生和药物输送方面具有巨大的潜力。在这篇综述中，我们介绍了常用于牙科研究的水凝胶分类，包括天然和合成水凝胶。此外，还讨论了这些水凝胶在牙髓修复、牙周组织、下颌和口腔软组织修复以及相关临床研究中的最新应用，包括水凝胶在牙科应用中使用的各种抗菌和组织生长促进策略。虽然水凝胶在口腔组织工程学中的研究越来越多，但要达到令人满意的临床效果，仍有一些挑战需要解决。本文总结了上述应用领域的当前问题，并讨论了可能的未来发展方向。
